1: 1-bromocyclohexane With magnesium in diethyl ether 2: succinic acid anhydride With copper(l) iodide in diethyl ether T=20°C; 14 h; 3: With hydrogenchloride; water in diethyl ether 0.5 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2009/92566 A1, 2009 ;
Location in patent: Page/Page column 68 ;
1: 1-bromocyclohexane With naphthalene; zinc in N,N-dimethyl-formamide T=20°C; 1 h; 2: 4'-iodoacetophenone With bis (triortho-tolylphosphine)palladium(II) chloride in tetrahydrofuran; N,N-dimethyl-formamide T=70°C; 3 h;
Brown, J. W.; Byron, D. J.; Southcott, M.; Wilson, R. C.; Guillon, D.; et al.
Molecular Crystals and Liquid Crystals (1969-1991), 1988 , vol. 159, p. 37 - 52
