1H-咪唑-4,5-二甲酸二乙酯合成路线 （共 12 条）
反应条件
sulfuric acid in ethanol; water
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5053408 A1, 1991 ;
反应条件
sulfuric acid 48 h; Inert atmosphereReflux;
参考文献
Malik, Chanchal K.; Das, Rajat S.; Basu, Ashis K.
Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 8 p. 376 - 381
反应条件
ammonium acetate in water; acetic acid; ethyl acetate T=10 - 50°C; 3.5 h; light-shielding conditions;
参考文献
EP2298763 A1, ;
Page/Page column 27-28 ;
EP 2298763 A1
反应条件
1: diethyl (2R,3R)-tartrate With 1,3-dibromo-5,5-dimethyl-hydantoin in ethyl acetate T=20°C; 3 h; 2: formaldehyd With ammonium acetate in water; acetic acid; ethyl acetate T=10 - 50°C; 3.5 h; Cooling with ice; Product distribution / selectivity;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2298763 A1, 2011 ;
Location in patent: Page/Page column 31 ;
EP 2298763 A1
反应条件
triethylamine in dichloromethane 0.5 h; Heating;
参考文献
Ivanov, E. I.; Bogatskii, A. V.; Abramovich, A. E.
Doklady Chemistry, 1980 , vol. 255, p. 516 - 518
Dokl. Akad. Nauk SSSR Ser. Khim., 1980 , vol. 255, # 2 p. 359 - 361
参考文献
Journal of the American Chemical Society, , vol. 74, p. 1084
反应条件
1: 1,3-dibromo-5,5-dimethyl-hydantoin; MeOAMVN / acetic acid / 3 h / 55 °C / light-shielding conditions 2: ammonium acetate / ethyl acetate; water; acetic acid / 3.5 h / 10 - 50 °C / light-shielding conditions View Scheme
参考文献
EP2298763 A1, ;
EP 2298763 A1
反应条件
ammonium acetate; acetic acid
参考文献
Anales de la Real Sociedad Espanola de Fisica y Quimica, Serie B: Quimica, , vol. 49, p. 599,601, 602
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Farina
Anales de la Real Sociedad Espanola de Fisica y Quimica, 1953 , vol. <B> 49, p. 599,601
反应条件
sodium hydride in N,N-dimethyl-formamide T=70 - 80°C; 4 h;
参考文献
Ivanov, E. I.; Polishchuk, A. A.; Mazepa, A. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 9 p. 1006 - 1008
Khimiya Geterotsiklicheskikh Soedinenii, 1992 , # 9 p. 1193 - 1195
