Chiralpak IA (immobilized amylose based stationary phase) column in ethanol; hexane; trifluoroacetic acid Resolution of racemate;

With  sodium hydroxide in  ethanol T=60°C; 4 h;   

Multi-step reaction with 5 steps 1: 97 percent / aq. N-benzyl-tri-n-butylammonium-chloride / CH2Cl2 / 43 h / 20 °C2: HCl / Heating3: 59 percent / NaOH / ethanol / 1.5 h / 23 - 25 °C4: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature5: 88 percent / 1N NaOH / ethanol / 4 h / 60 °C  

Multi-step reaction with 5 steps 1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C2: tetrahydrofuran; toluene / 3 h / Heating3: NaBH4 / methanol / 2 h / 15 °C4: 85 percent / PPh3, Et3N, CCl4 / acetonitrile / 15 h / Ambient temperature5: 88 percent / 1N NaOH / ethanol / 4 h / 60 °C