反应条件
1.1: oxalyl dichloride / chloroform / 4 h / |Reflux
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
2.2: 2.5 h / -78 - 20 °C
2.3: -10 - 20 °C
3.1: ammonia / water / 1 h / 65 °C
4.1: phosphorus oxytribromide / 1,2-dichloro-ethane / 1 h / 85 °C
View Scheme
参考文献
Furet, Pascal; Guagnano, Vito; Fairhurst, Robin A.; Imbach-Weese, Patricia; Bruce, Ian; Knapp, Mark; Fritsch, Christine; Blasco, Francesca; Blanz, Joachim; Aichholz, Reiner; Hamon, Jacques; Fabbro, Doriano; Caravatti, Giorgio
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3741 - 3748