3-[4-(溴甲基)苯基]-噻吩合成路线 （共 7 条）
参考文献
Merck and Co., Inc.
Patent: US5284841 A1, 1994 ;
反应条件
hydrogen bromide in acetic acid
T=5°C; 1 h;
参考文献
Touaibia, Mohamed; Desjardins, Marc-Andre; Provencal, Alexandre; Audet, Daniel; Medard, Christelle; Morin, Mario; Breau, Livain
Synthesis, 2004 , # 14 p. 2283 - 2288
反应条件
N-bromosuccinmide; magnesium; dibenzoyl peroxide in tetrahydrofuran; tetrachloromethane; diethyl ether
参考文献
Ciba-Geigy Japan Limited
Patent: US5780498 A1, 1998 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
1 h; Heating;
参考文献
Marwah, A. K.; Marwah, Padma; Rao, G. Shankar; Trivedi, B. S.; Rao, B. E.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 3 p. 197 - 200
反应条件
1.1: Mg / tetrahydrofuran
1.2: 64 percent / Ni(dppp)Cl2
2.1: 75 percent / HBr / acetic acid / 1 h / 5 °C
View Scheme
参考文献
Touaibia, Mohamed; Desjardins, Marc-Andre; Provencal, Alexandre; Audet, Daniel; Medard, Christelle; Morin, Mario; Breau, Livain
Synthesis, 2004 , # 14 p. 2283 - 2288
反应条件
1.1: 89 percent / imidazole / CH2Cl2 / 0.75 h
2.1: magnesium / tetrahydrofuran / 2 h / Heating
2.2: 67 percent Turnov. / NiCl2(dppe) / tetrahydrofuran / 3 h / Heating
3.1: 94 percent / tetrabutylammonium fluoride hydrate / tetrahydrofuran / 0.75 h / 25 °C
4.1: 51 percent / phosphorus tribromide / diethyl ether / 24 h / 20 °C
View Scheme
参考文献
Naudin, Eric; Ho, Hoang Anh; Bonin, Marc-Andre; Breau, Livain; Belanger, Daniel
Macromolecules, 2002 , vol. 35, # 13 p. 4983 - 4987
反应条件
1: 79.74 percent / 18-crown-6 / acetic acid / 8 h / Heating
2: 88.5 percent / aq. KOH / ethanol / 5 h / Heating
View Scheme
参考文献
Marwah, A. K.; Marwah, Padma; Rao, G. Shankar; Trivedi, B. S.; Rao, B. E.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 3 p. 197 - 200
