N-甲基哌嗪合成路线

参考文献

Schmutz,J. et al.
Helvetica Chimica Acta, 1967 , vol. 50, p. 245 - 254

109-01-3N-甲基哌嗪+

25697-38-5

2058-52-8氯噻平

参考文献

Nagarajan,K. et al.
Indian Journal of Chemistry, 1974 , vol. 12, p. 258 - 262

109-01-3N-甲基哌嗪+

99-96-7对羟基苯甲酸

85858-94-21-(4-羟基苯甲酰)-4-甲基哌嗪

参考文献

Storace, Louis; Anzalone, Luigi; Confalone, Pat N.; Davis, Wayne P.; Fortunak, Joseph M.; Giangiordano, Mark; Haley Jr., James J.; Kamholz, Kenneth; Li, Hui-Yin; Ma, Philip; Nugent, William A.; Parsons Jr., Rodney L.; Sheeran, Patrick J.; Silverman, Charlotte E.; Waltermire, Robert E.; Wood, Christopher C.
Organic Process Research and Development, 2002 , vol. 6, # 1 p. 54 - 63

109-01-3N-甲基哌嗪

85858-94-21-(4-羟基苯甲酰)-4-甲基哌嗪

参考文献

Zlatoidsky; Maliar
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 11 p. 895 - 899

109-01-3N-甲基哌嗪+

141-30-03,6-二氯哒嗪

27464-17-13-氯-6-(4-甲基哌嗪)-1-哒嗪

参考文献

Sengmany, Stephane; Vitu-Thiebaud, Arnaud; Le Gall, Erwan; Condon, Sylvie; Leonel, Eric; Thobie-Gautier, Christine; Pipelier, Muriel; Lebreton, Jacques; Dubreuil, Didier
Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 370 - 379

109-01-3N-甲基哌嗪+

446-52-62-氟苯甲醛

85803-62-92-(4-甲基哌嗪)苯甲醛

参考文献

PFIZER PRODUCTS INC.
Patent: WO2006/48727 A1, 2006 ;
Location in patent: Page/Page column 83 ;
WO 2006/048727 A1

109-01-3N-甲基哌嗪+

1635-61-62-硝基-5-氯苯胺

23491-48-75-(4-甲基哌嗪)-2-硝基苯胺

参考文献

UNIVERSITY OF DELHI; TANDON, Vibha
Patent: WO2004/63170 A1, 2004 ;
Location in patent: Page 7 ;

109-01-3N-甲基哌嗪+

2369-11-15-氟-2-硝基苯胺

23491-48-75-(4-甲基哌嗪)-2-硝基苯胺

参考文献

Renhowe, Paul A.; Pecchi, Sabina; Shafer, Cynthia M.; Machajewski, Timothy D.; Jazan, Elisa M.; Taylor, Clarke; Antonios-McCrea, William; McBride, Christopher M.; Frazier, Kelly; Wiesmann, Marion; Lapointe, Gena R.; Feucht, Paul H.; Warne, Robert L.; Heise, Carla C.; Menezes, Daniel; Aardalen, Kimberly; Ye, Helen; He, Molly; Le, Vincent; Vora, Jayesh; Jansen, Johanna M.; Wernette-Hammond, Mary Ellen; Harris, Alex L.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 2 p. 278 - 292

109-01-3N-甲基哌嗪+

1635-61-62-硝基-5-氯苯胺

20691-71-85-二甲基氨基-2-硝基苯胺+

23491-48-75-(4-甲基哌嗪)-2-硝基苯胺

参考文献

Harapanhalli; McLaughlin; Howell; Rao; Adelstein; Kassis
Journal of medicinal chemistry, 1996 , vol. 39, # 24 p. 4804 - 4809

109-01-3N-甲基哌嗪+

107-04-01-溴-2-氯乙烷

5753-26-4

参考文献

CHINA PHARMACEUTICAL UNIVERSITY; Xiang, Hua; Wang, Tianlin; Xiao, Hong; You, Qidong; Yao, Yao; Li, Xiaobo; Liao, Qingjiang
Patent: US2013/85140 A1, 2013 ;
Location in patent: Paragraph 0064; 0065 ;