potassium tert-butylate 1.) THF, RT, 0.5 h, 2.) THF, a) RT, 1 h, b) reflux, overnight; Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Deutsch, Howard M.; Shi, Qing; Gruszecka-Kowalik, Ewa; Schwer, Margaret M.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1201 - 1209
1: 2-bromo-pyridine With 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran T=-78°C; 2: With zinc(II) chloride in tetrahydrofuran T=-95 - 20°C; 3: iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran Heating; Further stages.;
参考文献
Karig, Gunter; Spencer, James A.; Gallagher, Timothy
Organic Letters, 2001 , vol. 3, # 6 p. 835 - 838
