1: 4-bromo-benzaldehyde dimethyl acetal With iodine; magnesium in tetrahydrofuran T=30 - 35°C; 2 h; 2: 2-bromo-pyridine With tetrakis(triphenylphosphine) palladium(0); zinc(II) chloride in tetrahydrofuran; toluene T=50°C; 2.5 h; 3: With hydrogenchloride; ammonia; water Conversion of starting material; more than 3 stages;
参考文献
Euticals Prime European Therapeutical SpA
Patent: US6765097 B1, 2004 ;
Location in patent: Page column 7-8 ;
1: 4-bromobenzaldehyde 2,2-dimethylpropane-1,3-diol acetal With iodine; magnesium in tetrahydrofuran T=30 - 35°C; 2 h; 2: 2-bromo-pyridine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; toluene T=50°C; 2.5 h; 3: With water Acidic aqueous solution; Conversion of starting material;
参考文献
Euticals Prime European Therapeutical SpA
Patent: US6765097 B1, 2004 ;
Location in patent: Page column 9 ;
1: 2-bromo-pyridine With n-butyllithium in diethyl ether; hexane T=-78°C; 0.5 h; 2: boric acid trimethyl ester in diethyl ether; hexane
参考文献
Fernando; Maharoof; Deshayes, Kurt D.; Kinstle, Thomas H.; Ogawa, Michael Y.
Journal of the American Chemical Society, 1996 , vol. 118, # 24 p. 5783 - 5790
