1: diisopropylamine in tetrahydrofuran Cooling with acetone-dry ice; 2: n-butyllithium in hexane 0.25 h; 3: 2,4-difluoro-1-bromobenzene; methyl iodide more than 3 stages;
参考文献
The Procter and Gamble Co.
Patent: US6348624 B1, 2002 ;
Location in patent: Page column 11 ;
Gilman; Langham; Willis
Journal of the American Chemical Society, 1940 , vol. 62, p. 346
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Gilman; Langham; Jacoby
Journal of the American Chemical Society, 1939 , vol. 61, p. 106,108