N-甲基-2-羟基乙胺合成路线 （共 285 条）
反应条件
in tetrahydrofuran; water
参考文献
Beecham Group p.l.c.
Patent: US5194443 A1, 1993 ;
参考文献
Cantello, Barrie C.C.; Cawthorne, Michael A.; Cottam, Graham P.; Duff, Peter T.; Haigh, David; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3977 - 3985
参考文献
Evers, Rainer
Zeitschrift fuer Chemie (Stuttgart, Germany), 1989 , vol. 29, # 12 p. 448 - 449
反应条件
sodium tetrahydroborate; iodine in tetrahydrofuran
参考文献
Lagasse, Franz; Tsukamoto, Masaki; Welch, Christopher J.; Kagan, Henri B.
Journal of the American Chemical Society, 2003 , vol. 125, # 25 p. 7490 - 7491
反应条件
in neat (no solvent)
byproducts: H2, SMe2; to BH3*SMe2 at 0°C under Ar was added the amine, stirred until evolution of H2 had ceased, Me2S was removed at high vac., heated to 120°C over a period of 90 min, left for 1.5 h at this temp.; cooling, distn. under Ar;
参考文献
Burgess, Kevin; Jaspars, Marcel
Organometallics, 1993 , vol. 12, p. 4197 - 4200
反应条件
in chloroform
Heating;
参考文献
Agnello,E.J.; Farina,P.R.
Journal of Medicinal Chemistry, 1972 , vol. 15, p. 363 - 365
反应条件
chlorosulfonic acid
T=140 - 150°C; P=20 Torr; 2 h;
参考文献
Smith, Richard H.; Wladkowski, Brian D.; Taylor, Jesse E.; Thompson, Erin J.; Pruski, Brunon; et al.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2097 - 2103
反应条件
1: With copper(I) bromide in 1,4-dioxane
T=50°C; 0.5 h;
2: With potassium tert-butylate in 1,4-dioxane; hexane
T=0 - 20°C; 0.583333 h;
参考文献
Ohta, Yusuke; Oishi, Shinya; Fujii, Nobutaka; Ohno, Hiroaki
Organic Letters, 2009 , vol. 11, # 9 p. 1979 - 1982
反应条件
in acetonitrile
1 h;
参考文献
Dobrydneva, Yuliya; Abelt, Christopher J.; Dovel, Beth; Thadigiri, Celina M.; Williams, Roy L.; Blackmore, Peter F.
Molecular Pharmacology, 2006 , vol. 69, # 1 p. 247 - 256
参考文献
Tonellato,U.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1977 , p. 821 - 827
