N-甲基-2-羟基乙胺合成路线 （共 285 条）
反应条件
Yield given. Multistep reaction;
参考文献
Reiter; Toldy; Schafer; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 41 - 53
参考文献
Chinoin
Patent: FR2303532DE2610865 , 19761976 ;
Chem.Abstr., 1977 , vol. 86, # 16440
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=0 - 20°C; 14 h;
参考文献
Afonso, Carlos A. M.; Lourenco, Nuno M. T.; De Rosatella, Andreia A.
Molecules, 2006 , vol. 11, # 1 p. 81 - 102
反应条件
hydrogenchloride in water
T=20°C; 2 h;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0235; 0311 ;
参考文献
Loftus, F.
Synthetic Communications, 1980 , vol. 10, # 1 p. 59 - 74
反应条件
triethylamine in dichloromethane
T=20°C; 15 h;
参考文献
Barth, Martine; Bondoux, Michel; Luccarini, Jean-Michel; Peyrou, Vincent; Dodey, Pierre; Pruneau, Didier; Massardier, Christine; Paquet, Jean-Luc
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2574 - 2584
反应条件
in ethanol
T=20°C; 1.5 h;
参考文献
Diorazio, Louis J.; Motherwell, William B.; Sheppard, Tom D.; Waller, Robert W.
Synlett, 2006 , # 14 p. 2281 - 2283
反应条件
in ethanol
T=20°C; 1.5 h;
参考文献
Diorazio, Louis J.; Motherwell, William B.; Sheppard, Tom D.; Waller, Robert W.
Synlett, 2006 , # 14 p. 2281 - 2283
参考文献
Saba, Shahrokh; Domkowski, Patrick W.; Firooznia, Fariborz
Synthesis, 1990 , # 10 p. 921 - 923
参考文献
Bernasconi,C.F. et al.
Journal of Organic Chemistry, 1973 , vol. 38, p. 2838 - 2842
