2,5-二甲基-2,5-己二醇合成路线 （共 107 条）
反应条件
1: hydrogenchloride / diethyl ether 2: hydrogenchloride / AlCl3 / toluene 3: AlCl3 / ethyl acetate; (2S)-N-methyl-1-phenylpropan-2-amine hydrate View Scheme
参考文献
Reinnervate Limited
Patent: US8293803 B2, 2012 ;
反应条件
1: HCl conc. / 3 h / 20 °C 2: 99 percent / AlCl3 / CH2Cl2 / 20 °C 3: 85 percent / Br2; AlCl3 / CH2Cl2 4: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 5: 2.38 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C 6: 88 percent / Pd(OAc)2; P(o-Tol)3; Et3N / dimethylformamide / 2 h / 50 °C View Scheme
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan
Patent: WO2011/103321 A1, 2011 ;
反应条件
1: conc. HCl, HCl gas / 0.25 h / 0 °C 2: 81.9 percent / AlCl3 / 24 h / Heating 3: 80.4 percent / AlCl3 / 1,2-dichloro-ethane View Scheme
参考文献
Selen Gurkan-Alp; Mumcuoglu, Mine; Andac, Cenk A.; Dayanc, Emre; Cetin-Atalay, Rengul; Buyukbingol, Erdem
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 346 - 354
反应条件
sulfuric acid; dihydrogen peroxide
参考文献
Dulog,L.; Sanner,A.
Tetrahedron Letters, 1966 , # 51 p. 6353 - 6358
参考文献
Criegee; Paulig
Chemische Berichte, 1955 , vol. 88, p. 712,713
反应条件
1: HCl conc. / 3 h / 20 °C 2: 99 percent / AlCl3 / CH2Cl2 / 20 °C 3: AlCl3 / CH2Cl2; nitromethane / 24 h / 15 - 30 °C View Scheme
参考文献
Faul; Ratz; Sullivan; Trankle; Winneroski
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5772 - 5782
反应条件
1: HCl conc. / 3 h / 20 °C 2: 99 percent / AlCl3 / CH2Cl2 / 20 °C 3: 85 percent / Br2; AlCl3 / CH2Cl2 4: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 5: 2.38 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5772 - 5782
反应条件
1: HCl conc. / 3 h / 20 °C 2: 99 percent / AlCl3 / CH2Cl2 / 20 °C 3: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C 4: 100 percent / aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan
Patent: WO2011/103321 A1, 2011 ;
反应条件
1: HCl conc. / 3 h / 20 °C 2: 99 percent / AlCl3 / CH2Cl2 / 20 °C 3: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C View Scheme
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan
Patent: WO2011/103321 A1, 2011 ;
反应条件
1: HCl conc. / 3 h / 20 °C 2: 99 percent / AlCl3 / CH2Cl2 / 20 °C 3: AlCl3 / CH2Cl2; nitromethane / 24 h / 15 - 30 °C 4: NaNH2 / tetrahydrofuran View Scheme
参考文献
Faul; Ratz; Sullivan; Trankle; Winneroski
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5772 - 5782
