2,5-二甲基-2,5-己二醇合成路线 （共 107 条）
反应条件
1: HCl conc. / 3 h / 20 °C 2: 99 percent / AlCl3 / CH2Cl2 / 20 °C 3: 85 percent / Br2; AlCl3 / CH2Cl2 4: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - 20 °C 5: 2.38 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C 6: 88 percent / Pd(OAc)2; P(o-Tol)3; Et3N / dimethylformamide / 2 h / 50 °C 7: H2O View Scheme
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan
Patent: WO2011/103321 A1, 2011 ;
反应条件
1: HCl conc. / 3 h / 20 °C 2: 99 percent / AlCl3 / CH2Cl2 / 20 °C 3: AlCl3 / CH2Cl2; nitromethane / 24 h / 15 - 30 °C 4: NaNH2 / tetrahydrofuran 5: 65 percent / Et2Zn / CH2Cl2 View Scheme
参考文献
Faul; Ratz; Sullivan; Trankle; Winneroski
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5772 - 5782
反应条件
chloro-trimethyl-silane; dimethyl sulfoxide in benzene T=20°C; 75 h;
参考文献
Synthesis, , # 3 p. 216 - 219
反应条件
Nafion-H T=130°C; 2 h;
参考文献
Olah, George A.; Fung, Alexander P.; Malhotra, Ripudaman
Synthesis, 1981 , # 6 p. 474 - 476
反应条件
N-phenyl-N-β-naphthylamine; toluene-4-sulfonic acid
参考文献
Pattison
Journal of Organic Chemistry, 1957 , vol. 22, p. 662
参考文献
Johnson; Johnson
Journal of the American Chemical Society, 1940 , vol. 62, p. 2619
参考文献
Bruson; Kroeger
Journal of the American Chemical Society, 1940 , vol. 62, p. 36,43
参考文献
Pattison
Journal of Organic Chemistry, 1957 , vol. 22, p. 662
反应条件
1: conc. HCl, HCl gas / 0.25 h / 0 °C 2: 80.4 percent / AlCl3 / 1 h / 0 °C 3: HNO3, H2SO4 / acetic acid 4: hydrogen / Pd/C / ethanol View Scheme
参考文献
Gurkan, A. Selen; Karabay, Arzu Z.; Buyukbingol, Zeliha; Buyukbingol, Erdem
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 468 - 479
反应条件
titanium tetrachloride
1) CH2Cl2, -40 to -30 deg C, 5 - 10 min, 2) CH2Cl2, 1 h; Yield given. Multistep reaction;
参考文献
Reetz, Manfred T.; Westermann, Juergen; Steinbach, Rainer
Journal of the Chemical Society, Chemical Communications, 1981 , # 5 p. 237 - 239
