7-乙基-10-羟基喜树碱中间体合成路线 （共 47 条）
反应条件
1: p-TSA*H2O / toluene; acetic acid / 18 h / 95 - 100 °C 2: pyridine / 2 h / 20 - 25 °C View Scheme
参考文献
AVRA LABORATORIES PVT. LTD.; ALLA, Venkata, Rama, Rao; RAO, Ramakrishna; RAMARAO, Chandrashekar; NANDIPATI, Ramadevi; CHAMLE, Vinay, Avinash
Patent: WO2012/32531 A1, 2012 ;
反应条件
hydrogenchloride; acetic acid 10 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 18 p. 2689 - 2700
反应条件
1: 86 percent / conc. HCl, glacial AcOH / 10 h / Heating 2: 50 percent / SnCl2, conc. HCl / 2 h / Ambient temperature View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
1: 85 percent / conc. HCl, glacial AcOH / 4 h / Heating 2: 74 percent / SnCl2, conc. HCl / 1.5 h / Ambient temperature 3: 60 percent / NaNO2, H2SO4 / H2O / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 18 p. 2689 - 2700
反应条件
trifluoroacetic acid in toluene T=80°C; 6 h;
参考文献
Rao, A. V. Rama; Rao, Ramakrishna; Yadav; Khagga, Mukkanti
Synthetic Communications, 2013 , vol. 43, # 12 p. 1661 - 1667
反应条件
1: trifluoroacetic acid / toluene / 20 h / 85 - 90 °C / Industry scale 2: N-methyl-pyrrolidine / dichloromethane / 20 - 45 °C 3: hydrogenchloride / water / 3 h / 70 °C View Scheme
参考文献
AVRA LABORATORIES PVT. LTD.; ALLA, Venkata, Rama, Rao; RAO, Ramakrishna; RAMARAO, Chandrashekar; NANDIPATI, Ramadevi; CHAMLE, Vinay, Avinash
Patent: WO2012/32531 A1, 2012 ;
反应条件
toluene-4-sulfonic acid; acetic acid in toluene
Heating;
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
