乙烯基硼酸甲基亚氨基二乙酸酯合成路线 （共 10 条）
反应条件
1: vinyl-magnesium bromide With boric acid trimethyl ester in tetrahydrofuran T=-78 - 23°C; 5.5 h; Inert atmosphere; 2: MIDA in dimethyl sulfoxide T=105 - 115°C; 2.16667 h; Inert atmosphere;
参考文献
Woerly, Eric M.; Miller, Jonathan E.; Burke, Martin D.
Tetrahedron, 2013 , vol. 69, # 36 p. 7732 - 7740
反应条件
in tetrahydrofuran; dimethyl sulfoxide; toluene T=95 - 115°C;
参考文献
Burke, Martin D.; Dick, Graham R.; Knapp, David M.; Gillis, Eric P.; Klubnick, Jenna A.
Patent: US2011/201806 A1, 2011 ;
Location in patent: Page/Page column 15 ;
反应条件
1: boron tribromide; trimethylsilyl ethylene in dichloromethane T=20°C; 13 h; 2: MIDA in dichloromethane; dimethyl sulfoxide T=23°C; 0.0833333 h;
参考文献
Burke, Martin D.; Gillis, Eric P.; Lee, Suk Joong; Knapp, David M.; Gray, Kaitlyn C.
Patent: US2009/30238 A1, 2009 ;
Location in patent: Page/Page column 23 ;
反应条件
1: trimethylsilyl ethylene With boron tribromide in dichloromethane T=0 - 23°C; Inert atmosphere; 2: sodium methyliminodiacetate in dichloromethane; acetonitrile T=0 - 23°C; Inert atmosphere;
参考文献
Uno, Brice E.; Gillis, Eric P.; Burke, Martin D.
Tetrahedron, 2009 , vol. 65, # 16 p. 3130 - 3138
反应条件
1: trimethylsilyl ethylene With boron tribromide in dichloromethane T=0°C; 1 h; Inert atmosphere; 2: MIDA With 2,6-dimethylpyridine in dichloromethane; dimethyl sulfoxide Inert atmosphere;
参考文献
Uno, Brice E.; Gillis, Eric P.; Burke, Martin D.
Tetrahedron, 2009 , vol. 65, # 16 p. 3130 - 3138
反应条件
palladium diacetate in tetrahydrofuran; diethyl ether T=0 - 23°C; Inert atmosphere;
参考文献
Tetrahedron, , vol. 65, # 16 p. 3130 - 3138
反应条件
1: With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in 1,4-dioxane T=20°C; 0.25 h; Inert atmosphere; 2: With potassium phosphate in 1,4-dioxane; water T=90°C; 3: With sodium hydroxide in 1,4-dioxane; water
参考文献
ASTRAZENECA AB
Patent: US2010/331341 A1, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=0 - 23°C; Inert atmosphere;
参考文献
Uno, Brice E.; Gillis, Eric P.; Burke, Martin D.
Tetrahedron, 2009 , vol. 65, # 16 p. 3130 - 3138
反应条件
1: With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in 1,4-dioxane
T=23°C; 0.166667 h; Inert atmosphere;
2: With potassium phosphate; water in 1,4-dioxane
T=23 - 100°C; 2.5 h; Inert atmosphere;
参考文献
Knapp, David M.; Gillis, Eric P.; Burke, Martin D.
Journal of the American Chemical Society, 2009 , vol. 131, p. 6961 - 6963
反应条件
1: With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in 1,4-dioxane
T=23°C; 0.166667 h; Inert atmosphere;
2: With potassium phosphate; water in 1,4-dioxane
T=23 - 100°C; 2.5 h; Inert atmosphere;
参考文献
Knapp, David M.; Gillis, Eric P.; Burke, Martin D.
Journal of the American Chemical Society, 2009 , vol. 131, p. 6961 - 6963
