反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) HMPA, room temperature, 15 min; 0 deg C, 30 min
2: H2 / Pd-C / methanol
3: 88 percent / diisobutylaluminium hydride / toluene / 1.) -78 deg C, 5 min, 2.) 0 deg C, 20 min
View Scheme
参考文献
Nakai; Konno; Kosuge; Sakuyama; Toda; Arai; Obata; Katsube; Miyamoto; Okegawa; Kawasaki
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 84 - 91
