3-(N-叔丁氧羰基氨基)苯甲酸合成路线 （共 18 条）
反应条件
triethylamine in 1,4-dioxane; water T=20°C; 24 h;
参考文献
Mu; Coffing; Riese II; Geahlen; Verdier-Pinard; Hamel; Johnson; Cushman
Journal of Medicinal Chemistry, 2001 , vol. 44, # 3 p. 441 - 452
反应条件
1: With lithium hydroxide; water in tetrahydrofuran; methanol T=20°C; 16 h; 2: With hydrogenchloride in water
参考文献
Eli Lilly and Company
Patent: US6639107 B1, 2003 ;
Location in patent: Page/Page column 37 ;
反应条件
sodium hydroxide in water; N,N-dimethyl-formamide T=0 - 20°C; 16 h;
参考文献
Wilbur, D. Scott; Pathare, Pradip M.; Hamlin, Donald K.; Wan, Feng
Patent: US2006/228325 A1, 2006 ;
Location in patent: Page/Page column 65 ;
反应条件
sodium hydroxide in tetrahydrofuran; water T=20°C; 4 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 63, p. 231 - 238
反应条件
carbonic acid di-tert-butyl ester in 1,4-dioxane; NaOH
参考文献
US2003/232815 A1, ;
Page 11 ;
反应条件
hydrogenchloride; triethylamine; aniline in dichloromethane; isobutyramide
反应条件
1: 1N aq. NaOH / Ambient temperature 2: dioxane; H2O / Ambient temperature View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 6 p. 647 - 652
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4094 - 4098
反应条件
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C 1.2: 20 °C 2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C 2.2: pH 10 View Scheme
参考文献
AC Immune, S.A.
Patent: US2011/280808 A1, 2011 ;
反应条件
1: isobutyl chloroformate / dichloromethane / 0.25 h 2: hydrogenchloride / water / 1 h 3: sodium azide; tetrabutylammomium bromide / acetone / 0.5 h 4: triphenylphosphine / tetrahydrofuran; water / 5 h View Scheme
参考文献
Nasim, Shama; Guzman, Monica L.; Jordan, Craig T.; Crooks, Peter A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4879 - 4883
