Boc-甘氨酸叔-丁基酯合成路线 （共 14 条）
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 1.) 30 min, 2.) 30 min;
参考文献
Vidal, Joelle; Damestoy, Stephanie; Guy, Laure; Hannachi, Jean-Christophe; Aubry, Andre; Collet, Andre
Chemistry - A European Journal, 1997 , vol. 3, # 10 p. 1691 - 1709
反应条件
sodium hydrogencarbonate; sodium chloride in chloroform; water 1.5 h; Heating;
参考文献
Muenster, Peter; Steglich, Wolfgang
Synthesis, 1987 , # 3 p. 223 - 225
反应条件
N,N-dimethylformamide dineopentyl acetal in toluene Eschenmoser method; 5.5 h; Reflux;
参考文献
Ducho, Christian; Hamed, Refaat B.; Batchelar, Edward T.; Sorensen, John L.; Odell, Barbara; Schofield, Christopher J.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 13 p. 2770 - 2779
反应条件
in tetrahydrofuran T=-78°C; 0.5 h;
参考文献
Vidal, Joelle; Guy, Laure; Sterin, Sebastien; Collet, Andre
Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4791 - 4793
反应条件
1: 92 percent / diethyl ether 2: 75 percent / toluene / 17 h / Heating 3: LiMCPBA / CH2Cl2 / 2 h / -78 °C 4: 35 percent / LiHMDS / tetrahydrofuran / -78 °C / 1.) 30 min, 2.) 30 min View Scheme
参考文献
Chemistry - A European Journal, , vol. 3, # 10 p. 1691 - 1709
反应条件
1: 75 percent / toluene / 17 h / Heating 2: LiMCPBA / CH2Cl2 / 2 h / -78 °C 3: 35 percent / LiHMDS / tetrahydrofuran / -78 °C / 1.) 30 min, 2.) 30 min View Scheme
参考文献
Chemistry - A European Journal, , vol. 3, # 10 p. 1691 - 1709
反应条件
1: LiMCPBA / CH2Cl2 / 2 h / -78 °C 2: 35 percent / LiHMDS / tetrahydrofuran / -78 °C / 1.) 30 min, 2.) 30 min View Scheme
参考文献
Chemistry - A European Journal, , vol. 3, # 10 p. 1691 - 1709
反应条件
tributylphosphine; sodium hydrogencarbonate 1.) Et2O, RT, 1 h, 2.) Et2O, -50 deg C, 1.5 h, 3.) -50 deg C to RT; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 36, # 48 p. 8857 - 8858
反应条件
1: 97 percent / NBS / CCl4 / 1 h / 20 °C / Irradiation 2: diisopropylethylamine / tetrahydrofuran / 0.25 h / -78 °C 3: tetrahydrofuran / 12 h / -78 deg C --> r.t. View Scheme
参考文献
Muenster, Peter; Steglich, Wolfgang
Synthesis, 1987 , # 3 p. 223 - 225
反应条件
zinc dibromide in dichloromethane dealkylation; 12 h;
参考文献
Wu, Yong-Qian; Limburg, David C.; Wilkinson, Douglas E.; Vaal, Mark J.; Hamilton, Gregory S.
Tetrahedron Letters, 2000 , vol. 41, # 16 p. 2847 - 2849
