N-甲基-N-甲氧基胺盐酸盐合成路线 （共 166 条）
参考文献
Major,R.T.; Ohly,K.W.
J. Med. Pharm. Chem., 1961 , vol. 4, # 2 p. 317 - 326
反应条件
1: With triethylamine
T=0°C;
2: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine
参考文献
Falkiewicz; Wisniowski; Kolodziejczyk; Wisniewski
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1393 - 1397
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in chloroform; acetonitrile
T=20°C; 1 h;
参考文献
SHIONOGI and CO., LTD.
Patent: EP1375486 A1, 2004 ;
Location in patent: Page 135 ;
反应条件
pyridine; water; methyllithium in diethyl ether; hexane
参考文献
Beak, Peter; Basha, Anwer; Kokko, Bruce; Loo, DeKai
Journal of the American Chemical Society, 1986 , vol. 108, # 19 p. 6016 - 6023
参考文献
Persson, Tobias; Nielsen, John
Organic Letters, 2006 , vol. 8, # 15 p. 3219 - 3222
参考文献
Jones; Major
Journal of the American Chemical Society, 1928 , vol. 50, p. 2743,2745
参考文献
Jones; Major
Journal of the American Chemical Society, 1928 , vol. 50, p. 2743,2745
反应条件
4-methyl-morpholine; Diethylcarbamazine; benzotriazol-1-ol in DMF (N,N-dimethyl-formamide)
T=20°C;
参考文献
Schering Corporation
Patent: US2004/122018 A1, 2004 ;
Location in patent: Page 349 ;
反应条件
pyridine
T=25°C; Inert atmosphere;
参考文献
Brachet, Etienne; Hamze, Abdallah; Peyrat, Jean-Francois; Brion, Jean-Daniel; Alami, Mouad
Organic Letters, 2010 , vol. 12, # 18 p. 4042 - 4045
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Zhao, Zhong; Araldi, Gian Luca; Xiao, Yufang; Reddy, Adulla P.; Liao, Yihua; Karra, Srinivasa; Brugger, Nadia; Fischer, David; Palmer, Elizabeth
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6572 - 6575
