3-溴-2,2-二氟丙酸乙酯合成路线 （共 6 条）
反应条件
magnesium bromide T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
Yamada, Shigeyuki; Kato, Masahiro; Komori, Yudai; Konno, Tsutomu; Ishihara, Takashi
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 15 p. 5493 - 5502
反应条件
sulfur(IV) fluoride in dichloromethane; water 18 h; Ambient temperature;
参考文献
Joyeau, Roger; Molines, Huguette; Labia, Roger; Wakselman, Michel
Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 370 - 374
参考文献
Gassen, K.-R.; Bielefeldt, D.; Marhold, A.; Andres P.
Journal of Fluorine Chemistry, 1991 , vol. 55, # 2 p. 149 - 162
反应条件
1: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C 2: hydrogen / palladium on activated charcoal / methanol / 10 h / 20 °C View Scheme
参考文献
Shionogi and Co., Ltd.; YUKIMASA, Akira
Patent: WO2012/144661 A1, 2012 ;
WO 2012/144661 A1
反应条件
sulfuric acid; water; zinc
T=100°C;
参考文献
Gassen, K.-R.; Bielefeldt, D.; Marhold, A.; Andres P.
Journal of Fluorine Chemistry, 1991 , vol. 55, # 2 p. 149 - 162
反应条件
chloro-trimethyl-silane; zinc in tetrahydrofuran
2 h;
参考文献
Fujimoto, Tatsuhiko; Tomata, Yoshihide; Kunitomo, Jun; Hirozane, Mariko; Marui, Shogo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6409 - 6413
