1-吡咯烷-1-环己烯合成路线 （共 146 条）
反应条件
(i) Et2O, (ii) H2O; Multistep reaction;
参考文献
Stork,G. et al.
Journal of the American Chemical Society, 1963 , vol. 85, p. 207 - 222
反应条件
1.1: dioxane / 16 h / Heating
1.2: water / dioxane / 1 h / Heating
2.1: KOH / methanol / 2 h / 20 °C
3.1: 2.86 g / sodium acetate; acetic anhydride / 3 h / Heating
4.1: DIBAL-H / tetrahydrofuran / -25 - 0 °C
5.1: tBuLi / tetrahydrofuran; pentane / -50 - 0 °C
5.2: 25 percent / tetrahydrofuran; pentane / 3 h / 20 °C
6.1: 99 percent / oxygen / Rose Bengal / methanol / 3 h / -78 °C / Irradiation
7.1: 52 percent / thionyl chloride / CH2Cl2 / 18 h / 20 °C
View Scheme
参考文献
Bagal, Sharanjeet K.; Adlington, Robert M.; Marquez, Rodolfo; Cowley, Andrew R.; Baldwin, Jack E.
Tetrahedron Letters, 2003 , vol. 44, # 27 p. 4993 - 4996
反应条件
1.1: 7.6 g / dioxane / 12 h / Heating
2.1: 90 percent / potassium hydroxide / H2O / 4 h / 20 °C
3.1: ethyl chloroformate; triethylamine / diethyl ether / 0.75 h / 20 °C
3.2: 53 percent / diethyl ether / 14 h / 0 - 10 °C
View Scheme
参考文献
Muthusamy, Sengodagounder; Babu, Srinivasarao Arulananda; Gunanathan, Chidambaram; Suresh, Eringathodi; Dastidar, Parthasarathi
Bulletin of the Chemical Society of Japan, 2002 , vol. 75, # 4 p. 801 - 811
反应条件
in toluene
18 h; Heating;
参考文献
Moeller, Kevin D.; Tinao, Luzviminda V.
Journal of the American Chemical Society, 1992 , vol. 114, # 3 p. 1033 - 1041
反应条件
C18H32ClIrOP2S; sodium t-butanolate in para-xylene
T=150°C; 24 h; Inert atmosphereSchlenk techniqueGloveboxSealed tube;
参考文献
Yao, Wubing; Zhang, Yuxuan; Jia, Xiangqing; Huang, Zheng
Angewandte Chemie - International Edition, 2014 , vol. 53, # 5 p. 1390 - 1394
Angew. Chem., 2014 , vol. 126, # 5 p. 1414 - 1418
参考文献
Stork; Landesman
Journal of the American Chemical Society, 1956 , vol. 78, p. 5128
参考文献
Stork; Landesman
Journal of the American Chemical Society, 1956 , vol. 78, p. 5128
反应条件
hydrogenchloride; triethylamine
1.) acetonitrile, 14 h, reflux, 2.) 1 h, room temperature; Yield given. Multistep reaction;
参考文献
Scholz, Dieter
Monatshefte fuer Chemie, 1984 , vol. 115, p. 655 - 658
反应条件
1: With triethylamine in 1,4-dioxane
6 h; Heating;
2: With hydrogenchloride
3 h; Heating;
参考文献
Tanyeli, Cihangir; Akhmedov, Idris M.; Yazicioglu, Emre Y.
Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9627 - 9629
反应条件
lead(IV) acetate; boron trifluoride diethyl etherate in benzene
30 h; Ambient temperature;
参考文献
Cekovic, Z.; Bosnjak, J.; Cvetkovic, M
Tetrahedron Letters, 1980 , vol. 21, p. 2675 - 2678
