乙基3-(2-萘基)丙酸酯合成路线 （共 9 条）
反应条件
1: With C16H18Cl2N2O4Pd2; potassium chloride; tetra-n-butylammonium acetate; potassium carbonate in N,N-dimethyl acetamide T=120°C; Heck reaction; 3.5 h; 2: With hydrogenchloride in water; ethyl acetate T=20°C; chemoselective reaction;
参考文献
Alacid, Emilio; Najera, Carmen
European Journal of Organic Chemistry, 2008 , # 18 p. 3102 - 3106
反应条件
1: With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); sodium acetate in 1-methyl-pyrrolidin-2-one T=140°C; 6 h; 2: With hydrogenchloride; water in 1-methyl-pyrrolidin-2-one
参考文献
Noel, Sebastien; Djakovitch, Laurent; Pinel, Catherine
Tetrahedron Letters, 2006 , vol. 47, # 23 p. 3839 - 3842
反应条件
water; sodium chloride in dimethyl sulfoxide T=130°C; 72 h;
参考文献
Bach, Anders; Eildal, Jonas N. N.; Stuhr-Hansen, Nicolai; Deeskamp, Rasmus; Gottschalk, Marie; Pedersen, Soren W.; Kristensen, Anders S.; Stromgaard, Kristian
Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1333 - 1346
反应条件
1: 2-(aminomethyl)naphthalene With palladium on activated charcoal T=170°C; 3 h; Irradiationmicrowave; 2: ethyl (triphenylphosphoranylidene)acetate in water T=20°C; Wittig reaction; 12 h; 3: With hydrogen in water T=20°C; 8 h;
参考文献
Chandrasekhar; Pavan Kumar Reddy; Nagesh; Raji Reddy
Tetrahedron Letters, 2007 , vol. 48, # 7 p. 1269 - 1271
反应条件
in ethanol; palladium; acetonitrile
参考文献
Sankyo Company, Limited
Patent: US5556864 A1, 1996 ;
US 5556864 A
反应条件
1: sodium ethanolate / ethanol / 3 h / Reflux 2: water; sodium chloride / dimethyl sulfoxide / 72 h / 130 °C View Scheme
参考文献
Jayasekara, P. Suresh; Barrett, Matthew O.; Ball, Christopher B.; Brown, Kyle A.; Hammes, Eva; Balasubramanian, Ramachandran; Harden, T. Kendall; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3874 - 3883
反应条件
(7,8,10-trimethyl-2,4-dioxo-4,10-dihydro-2H-benzo[g]pteridin-3-yl)acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene T=25.9°C; cat.: 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium salt; relative initial rate; var. cat.;
参考文献
Bergmann, N.; Schmidtchen, F. P.
Tetrahedron Letters, 1988 , vol. 29, # 48 p. 6235 - 6238
反应条件
lithium borohydride in tetrahydrofuran; toluene
T=100°C; 2 h; Inert atmosphere;
参考文献
Bach, Anders; Eildal, Jonas N. N.; Stuhr-Hansen, Nicolai; Deeskamp, Rasmus; Gottschalk, Marie; Pedersen, Soren W.; Kristensen, Anders S.; Stromgaard, Kristian
Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1333 - 1346
反应条件
1.1: trimethylaluminum / dichloromethane; toluene / 0.25 h / 0 - 20 °C / |Inert atmosphere
1.2: 24 h / 20 °C / |Inert atmosphere
2.1: tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Watanabe, Eiichi; Kaiho, Atsushi; Kusama, Hiroyuki; Iwasawa, Nobuharu
Journal of the American Chemical Society, 2013 , vol. 135, # 32 p. 11744 - 11747
