hydrogenchloride; triethylamine in water; dimethyl sulfoxide

1-methyl-pyrrolidin-2-one; sodium hydroxide; triethylamine in hexane

hydrogenchloride in water 8 h; Heating;

in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; sulfuric acid

lithium hexamethyldisilazane in tetrahydrofuran T=-13 - -5°C; 4.5 h;

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: 93 percent / various solvent(s) / -78 - 20 °C 2.1: 92 percent / hydrochloric acid / H2O / 8 h / Heating View Scheme

1.1: oxalyl chloride; N,N-dimethylformamide / CH2Cl2 / 1.5 h / 20 °C 1.2: 100 percent / ammonia gas / CH2Cl2 / 2 h / 0 °C 2.1: 1,2-dichloro-ethane / 4 h / Heating 2.2: 93 percent / dioxane / 4 h / 0 - 20 °C 3.1: 88 percent / potassium bis(trimethylsilyl)amide; 18-crown-6 / tetrahydrofuran; toluene / 1.5 h / Heating 4.1: 80 percent / sodium hydride; (2,4-dinitro-phenyl)-hydroxylamine / tetrahydrofuran / 1.5 h / Heating View Scheme

1.1: oxalyl chloride; N,N-dimethylformamide / CH2Cl2 / 1.5 h / 20 °C 1.2: 100 percent / ammonia gas / CH2Cl2 / 2 h / 0 °C 2.1: 1,2-dichloro-ethane / 4 h / Heating 2.2: 93 percent / dioxane / 4 h / 0 - 20 °C 3.1: 88 percent / potassium bis(trimethylsilyl)amide; 18-crown-6 / tetrahydrofuran; toluene / 1.5 h / Heating View Scheme

sulfuric acid; nitric acid 2 h; Ambient temperature;

1: With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 1.5 h; 2: With ammonia in dichloromethane T=0°C; 2 h;