3,5-二甲氧基苯甲酸合成路线 （共 127 条）
反应条件
1: 89 percent / (COCl)2 / benzene / 2 h, room t., 1 h, reflux
2: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
3: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
4: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
in diethyl ether
1.) from -78 deg C to 0 deg C , 1.5 h, 2.) RT, 18 h;
参考文献
Compton; Prescott Jr.; Martin; Siegel; Gordon; Razdan
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3310 - 3316
反应条件
1: thionyl chloride / 4 h / Heating
2: 1.) CdCl2, 2.) aq. NH4Cl / 1.) ether, from -5 deg C to reflux, 1 h, 2.) benzene, reflux, 1 h
View Scheme
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1924 , vol. <2> 107, p. 107
反应条件
in tetrahydrofuran
T=20°C; Substitution;
参考文献
Sinha, Surajit; Mandal, Bhubaneswar; Chandrasekaran, Srinivasan
Tetrahedron Letters, 2000 , vol. 41, # 17 p. 3157 - 3160
反应条件
hydrogenchloride; ammonia; lithium
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wilkie, John S.; Winzenberg, Kevin N.
Australian Journal of Chemistry, 1989 , vol. 42, # 8 p. 1207 - 1216
反应条件
1: 1 M B2H6 / tetrahydrofuran
2: pyridine / benzene / Ambient temperature
3: 23 percent Chromat. / Irradiation
View Scheme
参考文献
Pincock, J. A.; Wedge, P. J.
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5587 - 5595
反应条件
1: 89 percent / (COCl)2 / benzene / 2 h, room t., 1 h, reflux
2: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
3: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
4: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
