3,3-二溴-1H-吡咯并[2,3-b]吡啶-2(3H)-酮合成路线 （共 10 条）
反应条件
pyridinium hydrobromide perbromide in water; tert-butyl alcohol
参考文献
E. R. Squibb and Sons, Inc.
Patent: US6117885 A1, 2000 ;
反应条件
in BuOH; dichloromethane; water
参考文献
Yu, Kuo-Long; Civiello, Rita L.; Combrink, Keith D.; Gulgeze, Hatice Belgin; Sin, Ny; Wang, Xiangdong; Meanwell, Nicholas; Venables, Brian Lee; Zhang, Yi; Pearce, Bradley C.; Yin, Zhiwei; Thuring, Jan Willem
Patent: US2002/99208 A1, 2002 ;
反应条件
pyridinium tribromide; acetic acid in ethanol; tert-butyl alcohol 2 h;
参考文献
SUGEN, INC.
Patent: WO2005/5378 A2, 2005 ;
Location in patent: Page/Page column 43 ;
WO 2005/005378 A2
反应条件
pyridinium hydrobromide perbromide in tert-butyl alcohol T=25°C; 5.5 h;
参考文献
Marfat, Anthony; Carta, Michael P.
Tetrahedron Letters, 1987 , vol. 28, # 35 p. 4027 - 4030
反应条件
in tert-butyl alcohol
参考文献
SmithKline Beecham Corporation
Patent: US6624171 B1, 2003 ;
US 6624171 B1
反应条件
acetic acid; zinc in acetonitrile
参考文献
Sugen, Inc.
Patent: US6350754 B2, 2002 ;
Location in patent: Page column 26 ;
反应条件
ammonium chloride in tetrahydrofuran; CHCl3:MeOH
参考文献
SmithKline Beecham Corporation
Patent: US6624171 B1, 2003 ;
US 6624171 B1
反应条件
methanol; water 24 h; Heating / reflux;
参考文献
SUGEN, INC.
Patent: WO2005/5378 A2, 2005 ;
Location in patent: Page/Page column 43 ;
WO 2005/005378 A2
反应条件
bromine in water; tert-butyl alcohol T=0 - 20°C;
参考文献
WO2003/82869 A1, ;
Page/Page column 23 ;
WO 03/082869 A1
反应条件
bromine; sodium hydrogencarbonate in water; tert-butyl alcohol
参考文献
US6369086 B1, ;
US 6369086 B1
