3',4',5'-三甲氧基苯乙酮合成路线 （共 90 条）
反应条件
1: With acetic acid in ethanol
T=80°C; Fischer Indole Synthesis;
2: T=120°C;
参考文献
Karaaslan, Cigdem; Kadri, Hachemi; Coban, Tulay; Suzen, Sibel; Westwell, Andrew D.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2671 - 2674
反应条件
sodium hydroxide in methanol
Claisen Schmidt condensation; Cooling;
参考文献
Batovska, Daniela; Parushev, Stoyan; Stamboliyska, Bistra; Tsvetkova, Iva; Ninova, Mariana; Najdenski, Hristo
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 2211 - 2218
参考文献
Aeppli; Bernauer; Schneider; et al.
Helvetica Chimica Acta, 1980 , vol. 63, # 3 p. 630 - 644
反应条件
1: HCl
2: (i) nBuLi, (ii) /BRN= 1021957/
View Scheme
参考文献
Pettit,G.R.; Alkalay,D.S.
Journal of Organic Chemistry, 1960 , vol. 25, p. 1363 - 1365
反应条件
hydrogenchloride in ethanol
7 h; Heating;
参考文献
Magdziarz, Tomasz; Lozowicka, Bozena; Gieleciak, Rafal; Bak, Andrzej; Polanski, Jaroslaw; Chilmonczyk, Zdzislaw
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 5 p. 1630 - 1643
反应条件
nitric acid; acetic acid
参考文献
Royer,R. et al.
Bulletin de la Societe Chimique de France, 1974 , p. 1691 - 1694
参考文献
Harding
Journal of the Chemical Society, 1914 , vol. 105, p. 2794
反应条件
hydrogenchloride; paraformaldehyde in ethanol; acetone
参考文献
Merck and Co., Inc.
Patent: US4977146 A1, 1990 ;
反应条件
hydrogenchloride in ethanol
1 h; Heating;
参考文献
Girotra, N. N.; Biftu, T.; Ponpipom, M. M.; Acton, J. J.; Alberts, A. W.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3474 - 3482
反应条件
sodium hydroxide in methanol
Claisen Schmidt condensation; Cooling;
参考文献
Batovska, Daniela; Parushev, Stoyan; Stamboliyska, Bistra; Tsvetkova, Iva; Ninova, Mariana; Najdenski, Hristo
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 2211 - 2218
