2-苯乙基环己烷-1-酮合成路线 （共 14 条）
反应条件
1: N-cyclohexylidene-cyclohexylamine With sec.-butyllithium in tetrahydrofuran
T=-78°C; 1 h;
2: (2-chloroethyl)-benzene in tetrahydrofuran
T=20°C; 24 h;
3: With hydrogenchloride in tetrahydrofuran; water
参考文献
Lagu, Bharat; Liotta, Fina; Pan, Meng; Wachter, Michael P.; Xia, Mingde Xia
Patent: US2005/228034 A1, 2005 ;
Location in patent: Page/Page column 120-122 ;
US 20050228034 A1
反应条件
1: in hexane
T=50°C; 12 h;
2: With acetic acid in hexane
T=20°C; 1 h;
参考文献
Nakamura, Masaharu; Hatakeyama, Takuji; Nakamura, Eiichi
Journal of the American Chemical Society, 2004 , vol. 126, # 38 p. 11820 - 11825
反应条件
in tetrahydrofuran
T=-40°C; 0.166667 h; quench: glacial AcOH;
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Sambri, Letizia; Marcantoni, Enrico
Tetrahedron Letters, 1994 , vol. 35, # 46 p. 8651 - 8654
反应条件
1: 3-phenyl-1,1,-bis(phenylthio)propane With Cp2Ti[P(OEt)3]2 in tetrahydrofuran
T=20°C; complexation; 0.25 h;
2: 1-bromo-4-cyano-butane in tetrahydrofuran
T=20°C; Alkylation; 2 h;
3: With sodium hydroxide
Hydrolysis;
参考文献
Takeda, Takeshi; Taguchi, Haruhiko; Fujiwara, Tooru
Tetrahedron Letters, 2000 , vol. 41, # 1 p. 65 - 68
反应条件
potassium tert-butylate in dimethyl sulfoxide
T=40°C; Addition; 15 h;
参考文献
Rodriguez, Alain Louis; Bunlaksananusorn, Tanasri; Knochel, Paul
Organic Letters, 2000 , vol. 2, # 21 p. 3285 - 3287
反应条件
1: 72 percent / NaH, NaI / dimethylformamide; benzene / 1 h / Heating
2: LiCl / dimethylformamide / 7 h / 145 - 150 °C
View Scheme
参考文献
Jeyaraj, Duraiswamy A.; Kapoor, Kamal K.; Yadav, Veejendra K.; Gauniyal, Harsh M.; Parvez, Masood
Journal of Organic Chemistry, 1998 , vol. 63, # 2 p. 287 - 294
反应条件
1: 72 percent / NaH, NaI / dimethylformamide; benzene / 1 h / Heating
2: LiCl / dimethylformamide / 7 h / 145 - 150 °C
View Scheme
参考文献
Jeyaraj, Duraiswamy A.; Kapoor, Kamal K.; Yadav, Veejendra K.; Gauniyal, Harsh M.; Parvez, Masood
Journal of Organic Chemistry, 1998 , vol. 63, # 2 p. 287 - 294
反应条件
(i) EtMgBr, THF, (ii) /BRN= 507487/, (iii) aq. HCl; Multistep reaction;
参考文献
Stork,G.; Dowd,S.R.
Journal of the American Chemical Society, 1963 , vol. 85, p. 2178 - 2180
反应条件
1: lithium diisopropyl amide / tetrahydrofuran / -78 - 20 °C / |Inert atmosphere
2: oxalic acid / 3 h / 20 °C
View Scheme
参考文献
Liu, Jie; Dang, Hai-Shan
Journal of Chemical Research, 2012 , vol. 36, # 12 p. 732 - 735
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hegedus,L.S.; Williams,R.E.; Mcguire,M.A.
Journal of the American Chemical Society, 1980 , vol. 102, p. 4973
