2-甲基-1H-吡咯并[3,2-c]吡啶合成路线 （共 11 条）
反应条件
hydrogenchloride in 1,4-dioxane 15 h;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2005/30213 A1, 2005 ;
Location in patent: Page/Page column 192 ;
WO 2005/030213 A1
反应条件
hydrogenchloride in water T=20°C; 16 - 18 h;
参考文献
OXAGEN LIMITED
Patent: WO2005/121141 A1, 2005 ;
Location in patent: Page/Page column 13; 21 ;
WO 2005/121141 A1
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=120°C; 10 h;
参考文献
Tetrahedron Letters, , vol. 39, # 29 p. 5159 - 5162
反应条件
1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / -78 - 20 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol / 60 h / 70 °C View Scheme
参考文献
WO2012/88469 A1, ;
WO 2012/088469 A1
反应条件
hydrogenchloride T=90°C; 4 h;
参考文献
Journal of Organic Chemistry, , vol. 53, # 12 p. 2740 - 2744
反应条件
sodium ethanolate T=350°C;
参考文献
Journal of the Chemical Society, , p. 198
反应条件
1: 1.) n-BuLi, TMEDA, 2.) I2 / 1.) THF, a) -75 deg C, 15 min, b) -10 deg C, 2 h, 2.) -75 deg C, 2 h 2: 1.) tert-BuOK / 1.) liq. NH3, reflux, 5 min, 2.) irradiation 3: 3 N HCl / 4 h / 90 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 12 p. 2740 - 2744
反应条件
1: 1.) tert-BuOK / 1.) liq. NH3, reflux, 5 min, 2.) irradiation 2: 3 N HCl / 4 h / 90 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 12 p. 2740 - 2744
反应条件
2: sodium ethylate / 350 °C View Scheme
参考文献
Journal of the Chemical Society, , p. 198
反应条件
1: SOCl2 / 180 - 190 °C / Erhitzen des Reaktionsprodukts mit konz. wss. NH3 3: sodium ethylate / 350 °C View Scheme
参考文献
Journal of the Chemical Society, , p. 198
