N-苄氧羰基-L-丝氨酸合成路线 （共 73 条）
反应条件
4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=-10°C; 2 h;
参考文献
Ziora, Zyta; Kasai, Soko; Hidaka, Koushi; Nagamine, Ayaka; Kimura, Tooru; Hayashi, Yoshio; Kiso, Yoshiaki
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1629 - 1633
反应条件
triphenylphosphine in tetrahydrofuran; NaHSO4; NaH; dichloromethane
参考文献
Dressman, Bruce A.; Fritz, James E.; Hammond, Marlys; Hornback, William J.; Kaldor, Stephen W.; Kalish, Vincent J.; Munroe, John E.; Reich, Siegfried Heinz; Tatlock, John H.; Shepherd, Timothy A.; Rodriguez, Michael J.
Patent: US2003/216569 A1, 2003 ;
反应条件
in tetrahydrofuran; NaHSO4; NaH; dichloromethane
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US5527829 A1, 1996 ;
反应条件
in tetrahydrofuran; NaHSO4; NaH; dichloromethane
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US5484926 A1, 1996 ;
反应条件
1: 3.8 g
2: dicyclohexylcarbodiimide (DCC) / dioxane; ethyl acetate / 1.) 0 deg C, 1 h; 2.) RT
View Scheme
参考文献
Ferrari, B.; Pavia, A. A.
Tetrahedron, 1985 , vol. 41, # 10 p. 1939 - 1944
反应条件
(i) H2SO4, CH2Cl2, (ii) H2, Pd-BaSO4, MeOH; Multistep reaction;
参考文献
Beyerman,H.C.; Bontekoe,J.S.
Proceedings of the Chemical Society, London, 1961 , p. 249
反应条件
1: N-methyl-morpholine / 1 h / Ambient temperature
2: 1.) Piv-Cl, pyridine 2.) citric acid / 1.) THF, -15 - 0 deg C, 1 h 5 min 2.) water
View Scheme
参考文献
Anteunis, M.J.O.; Becu, Chr.; Becu, F.
Bulletin des Societes Chimiques Belges, 1987 , vol. 96, # 2 p. 133 - 136
反应条件
1: N-methyl morpholine / CH2Cl2 / 0.33 h / -15 °C
2: N-methyl morpholine / CH2Cl2 / -15 - 20 °C
View Scheme
参考文献
Dziedzic, Pawel; Zou, Weibiao; Hafren, Jonas; Cordova, Armando
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 1 p. 38 - 40
反应条件
sulfuric acid in dichloromethane
T=-25 - 20°C; Alkylation;
参考文献
Strazzolini, Paolo; Scuccato, Massimo; Giumanini, Angelo G.
Tetrahedron, 2000 , vol. 56, # 22 p. 3625 - 3633
反应条件
in tetrahydrofuran; dichloromethane
Ambient temperature;
参考文献
Thierry, Josiane; Yue, Chongwei; Potier, Pierre
Tetrahedron Letters, 1998 , vol. 39, # 12 p. 1557 - 1560
