4'-甲基联苯-2-羧酸甲酯合成路线 （共 42 条）
参考文献
Kuduk, Scott D.; Bock, Mark G.; Feng, Dong-Mei; Su, Dai-Shi; Wai, Jenny Miu-Chun
Patent: US2004/44041 A1, 2004 ;
Location in patent: Page/Page column 14 ;
US 20040044041 A1
反应条件
hydrogenchloride; n-butyllithium; triphenylphosphine; lithium chloride; nickel dichloride in tetrahydrofuran; water
参考文献
Dinamite Dipharma S.p.A.
Patent: EP1044956 A1, 2000 ;
反应条件
tetra-butylammonium acetate; Pd EnCat-30TM in ethanol T=120°C; Suzuki cross-coupling; 0.166667 h; microwave irradiation;
参考文献
Baxendale, Ian R.; Griffiths-Jones, Charlotte M.; Ley, Steven V.; Tranmer, Geoffrey K.
Chemistry - A European Journal, 2006 , vol. 12, # 16 p. 4407 - 4416
反应条件
potassium fluoride; palladium diacetate in toluene T=80°C; Suzuki-Miyaura coupling; 2 h;
参考文献
Suzuki, Ken; Fontaine, Arnaud; Hori, Yoji; Kobayashi, Tohru
Synlett, 2007 , # 20 p. 3206 - 3208
反应条件
n-butyllithium; Zinc chloride; tetrakis (triphenylphosphine) palladium (0) in tetrahydrofuran; hexane; chloroform; water
参考文献
US5236937 A1, ;
US 5236937 A
反应条件
sulfuric acid in methanol
反应条件
pyridine; triphenylphosphine; nickel dichloride
反应条件
1: K3PO4; 2-(dicyclohexylphosphino)biphenyl based D-gluconamide / Pd(OAc)2 / H2O / 16 h / 80 °C 2: BF3*OEt2 / Heating View Scheme
参考文献
Tetrahedron, , vol. 58, # 29 p. 5779 - 5787
参考文献
US5128355 A1, ;
US 5128355 A
反应条件
1: 4'-methyl-biphenyl-2-carboxylic acid With potassium carbonate in acetone 0.25 h; 2: methyl iodide in acetone 24 h; Reflux;
参考文献
Catalano, Alessia; Carocci, Alessia; Di Mola, Antonia; Bruno, Claudio; Vanderheyden, Patrick M. L.; Franchini, Carlo
Archiv der Pharmazie, 2011 , vol. 344, # 9 p. 617 - 626
