4’-甲基-[1,1’-联苯]-2-甲酸叔丁酯合成路线 （共 22 条）
反应条件
hydrogenchloride; tert.-butyl lithium; zinc(II) chloride in tetrahydrofuran; hexane; ethyl acetate; pentane
参考文献
Merck and Co., Inc.
Patent: US5102880 A1, 1992 ;
US 5102880 A
反应条件
hydrogenchloride; tert.-butyl lithium; zinc(II) chloride in tetrahydrofuran; pentane
参考文献
Merck and Co., Inc.
Patent: US5240928 A1, 1993 ;
US 5240928 A
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethanol; toluene 4 h; Heating;
参考文献
Schoen; Pisano; Prendergast; Wyvratt Jr.; Fisher; Cheng; Chan; Butler; Smith; Ball
Journal of Medicinal Chemistry, 1994 , vol. 37, # 7 p. 897 - 906
反应条件
in diethyl ether; dichloromethane
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5378704 A1, 1995 ;
US 5378704 A
反应条件
1: With trichlorophosphate in toluene T=20°C; 6 h; 2: With sodium hydroxide in water
参考文献
Sumika Fine Chemicals, Co.,Ltd.
Patent: US6369266 B1, 2002 ;
Location in patent: Example II-3 ;
反应条件
in tetrahydrofuran T=25°C; 1 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
参考文献
G.D. Searle and Co.
Patent: US2001/20100 A1, 2001 ;
US 20010020100 A1
反应条件
1: 4'-methyl-biphenyl-2-carboxylic acid With oxalyl dichloride in dichloromethane T=0 - 20°C; 3 h; 2: potassium tert-butylate in tetrahydrofuran T=10 - 20°C; 1 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374,17
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374
反应条件
1: dicyclohexyl-carbodiimide / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 h / 20 °C / Inert atmosphere 2: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 0.67 h / 100 °C / Sealed vial View Scheme
反应条件
1: 99 percent / NaOH / H2O; methanol / Heating 2: 94 percent / sulfuric acid / diethyl ether / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 15 p. 2172 - 2181
