2-氰基-4'-甲基联苯合成路线 （共 139 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene Stille Cross Coupling; Reflux;
参考文献
EP2662379 A1, ;
Paragraph 0102 ;
反应条件
bathophenanthroline; sodium t-butanolate T=182°C; 6 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 132, # 44 p. 15537 - 15539
反应条件
nickel; zinc(II) chloride in tetrahydrofuran T=50 - 60°C; various double metal catalysts, various yield of products; Product distribution;
参考文献
Tetrahedron Letters, , vol. 39, # 40 p. 7275 - 7278
反应条件
bis-triphenylphosphine-palladium(II) chloride; tributyltin chloride; iodine; magnesium; lithium chloride 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h; Yield given. Multistep reaction;
参考文献
Farmaco, , vol. 52, # 3 p. 147 - 155
反应条件
palladium diacetate; trifluoroacetic acid; silver(l) oxide Inert atmosphere;
参考文献
Chemical Communications, , vol. 49, # 1 p. 69 - 71
反应条件
bathophenanthroline; sodium t-butanolate T=178°C; 6 h; Inert atmosphere;
参考文献
Shirakawa, Eiji; Itoh, Ken-Ichi; Higashino, Tomohiro; Hayashi, Tamio
Journal of the American Chemical Society, 2010 , vol. 132, # 44 p. 15537 - 15539
反应条件
palladium on activated charcoal in benzonitrile 8 h; Heatingother solvents, catalysts, time; Product distribution;
参考文献
Synthetic Communications, , vol. 26, # 24 p. 4633 - 4639
反应条件
potassium hydroxide in ethylene glycol T=170°C; 48 h;
参考文献
Catalano, Alessia; Carocci, Alessia; Di Mola, Antonia; Bruno, Claudio; Vanderheyden, Patrick M. L.; Franchini, Carlo
Archiv der Pharmazie, 2011 , vol. 344, # 9 p. 617 - 626
参考文献
Shashikumar, Nellisara D.; Krishnamurthy, Ganganaika; Bhojyanaik, Halehatti S.; Lokesh, Mayasandra R.; Jithendrakumara, Kaginalli S.
Journal of Chemical Sciences, 2014 , vol. 126, # 1 p. 205 - 212
反应条件
1: NBS, AIBN / CCl4 / Heating 2: NaN3 / dimethylformamide / 24 h / Ambient temperature 3: H2 / 10percent Pd/C / ethanol / 20 h / 2068.6 Torr View Scheme
参考文献
Huang, Horng-Chih; Reitz, David B.; Chamberlain, Timothy S.; Olins, Gillian M.; Corpus. Valerie M.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2172 - 2181
