反应条件
1.1: potassium hydroxide; bromine / water / 20 h / 5 - 10 °C / |Industrial scale 2.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / |Large scale 2.2: 1 h / 20 °C / |Reflux; |Large scale 3.1: L-Selectridereg; / tetrahydrofuran / 1 h / |Reflux; |Large scale 4.1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / n-heptane / 0.25 h / 78 °C 5.1: 2,4,6-trimethyl-pyridine / toluene / 2.5 h / 110 °C / |Large scale 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 9 h / 66 °C 7.1: tetrahydrofuran / 7 h / 10 °C / |Irradiation 8.1: tetrahydrofuran / 85 h / 25 °C View Scheme
参考文献
Shimizu, Hitoshi; Shimizu, Kazuki; Kubodera, Noboru; Mikami, Tetsuhiro; Tsuzaki, Kaname; Suwa, Hiroyuki; Harada, Koji; Hiraide, Akira; Shimizu, Motoki; Koyama, Kaichiro; Ichikawa, Yoshihide; Hirasawa, Daisuke; Kito, Yasushi; Kobayashi, Mio; Kigawa, Masaharu; Kato, Masahiro; Kozono, Toshiro; Tanaka, Hideki; Tanabe, Makoto; Iguchi, Masanori; Yoshida, Mitsutaka
Organic Process Research and Development, 2005 , vol. 9, # 3 p. 278 - 287
