2-甲基-3-丁烯-2-醇合成路线 （共 471 条）
反应条件
1: 42.5 percent / orthophosphoric acid (85percent) / petroleum ether / 35 - 40 °C
2: 40 percent / DDQ / benzene / Heating
View Scheme
参考文献
Ahluwalia, V. K.; Arora, K. K.; Mukherjee, Keya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1291 - 1292
反应条件
1: 30 percent / BF3*Et2O / dioxane / 8 h / Heating
2: DDQ / benzene / 48 h / Heating
View Scheme
参考文献
Shah; Desai; Trivedi
Pharmazie, 1983 , vol. 38, # 7 p. 439 - 441
反应条件
1: 52.5 percent / orthophosphoric acid (85percent) / petroleum ether / 12 h / 35 - 40 °C
2: 80 percent / DDQ / benzene / 30 h / Heating
View Scheme
参考文献
Ahluwalia, V. K.; Arora, K. K.; Mukherjee, Keya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1291 - 1292
反应条件
1: formic acid / 100 °C / Inert atmosphere
2: AlCl3, aluminium chloride / dichloromethane / 1.5 h / -10 - -5 °C / Inert atmosphere
3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 3 h / 110 °C / Inert atmosphere
4: potassium carbonate / acetone / 0 - 20 °C / Inert atmosphere
5: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Harel, Dipak; Schepmann, Dirk; Prinz, Helge; Brun, Reto; Schmidt, Thomas J.; Wuensch, Bernhard
Journal of Medicinal Chemistry, 2013 , vol. 56, # 18 p. 7442 - 7448
反应条件
(1,10-phenanthroline)palladium(II) acetate
T=85°C;
参考文献
Wei, Xudong; Lorenz, Jon C.; Kapadia, Suresh; Saha, Anjan; Haddad, Nizar; Busacca, Carl A.; Senanayake, Chris H.
Journal of Organic Chemistry, 2007 , vol. 72, # 11 p. 4250 - 4253
反应条件
citric acid
15 h; Heating;
参考文献
Cannon, Jack R.; Feutrill, Geoffrey I.; Wong, Laurence C. H.
Australian Journal of Chemistry, 1983 , vol. 36, # 12 p. 2575 - 2580
反应条件
1: citric acid / H2O / 17 h / 80 °C
2: 18.6 g / anhyd. K2CO3 / acetone / 6 h / Heating
View Scheme
参考文献
Manners, Gary D.; Wong, Rosalind Y.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1849 - 1854
反应条件
sodium hypochlorite
3 h; Ambient temperature; Further byproducts given;
参考文献
Bentley, Stuart; Goosen, Andre; Laue, Hugh A. H.; Taljaard, Benjamin
Journal of Chemical Research, Miniprint, 1991 , p. 1566 - 1590
反应条件
trifluoroacetic acid
3 h; Ambient temperature; Further byproducts given;
参考文献
Bentley, Stuart; Goosen, Andre; Laue, Hugh A. H.; Taljaard, Benjamin
Journal of Chemical Research, Miniprint, 1991 , p. 1566 - 1590
反应条件
sodium hypochlorite
0.666667 h; Ambient temperaturepH 5; var. positive chlorination reagents, reaction times, pH, reagent/MBE ratios, and temp.; Product distributionMechanism;
参考文献
Bentley, Stuart; Goosen, Andre; Laue, Hugh A. H.; Taljaard, Benjamin
Journal of Chemical Research, Miniprint, 1991 , p. 1566 - 1590
