2-甲基-3-丁烯-2-醇合成路线 （共 471 条）
反应条件
1: 25 percent / ortophosphoric acid / 12 h / 20 °C
2: 98 percent / boron trichloride / CH2Cl2 / 2 h / 0 °C
3: 1.) potassium t-butoxide, 2.) pyridine, 3.) m-chloroperbenzoic acid
4: 19 percent / NaOH / H2O / 3 h / other conditions (1M NaOH-EtOH)
View Scheme
参考文献
Baird, Kenneth J.; Grundon, Michael F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1820 - 1825
反应条件
2: palladium/calcium carbonate; diethyl ether / Hydrogenation
View Scheme
参考文献
Nesmejanow et al.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1949 , p. 623,627136,138
Chem.Abstr., 1950 , p. 3920
反应条件
1: Isopropyl(H)=NBn With titanium(IV) isopropylate; n-butyllithium in diethyl ether; hexane
T=-78 - 20°C; 1 h; Inert atmosphere;
2: 1,1-dimethylallyl alcohol With n-butyllithium in tetrahydrofuran; diethyl ether; hexane
T=-78 - 20°C; 12 h; Inert atmosphere;
3: With water; ammonium chloride in tetrahydrofuran; diethyl ether; hexane
0.5 h; Inert atmosphere;
参考文献
Tarselli, Michael A.; Mlcalizio, Glenn C.
Organic Letters, 2009 , vol. 11, # 20 p. 4596 - 4599
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / |Inert atmosphere
1.2: 4 h / 20 °C / |Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -10 °C / |Inert atmosphere
2.2: 16 h / -10 °C / |Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / -10 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Evans, P. Andrew; Oliver, Samuel; Chae, Jungha
Journal of the American Chemical Society, 2012 , vol. 134, # 47 p. 19314 - 19317
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane
2: tributylphosphine; potassium carbonate; bis(dibenzylideneacetone)-palladium(0) / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Vasil'ev; Lyubimov; Serebryakov; Davankov; Struchkova; Zlotina
Russian Chemical Bulletin, 2010 , vol. 59, # 3 p. 605 - 610
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane
2: potassium carbonate; bis(dibenzylideneacetone)-palladium(0); 1-phenoxy-2-phenyl-hexahydro-pyrrolo[1,2-c][1,3,2]diazaphopsphole / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Vasil'ev; Lyubimov; Serebryakov; Davankov; Struchkova; Zlotina
Russian Chemical Bulletin, 2010 , vol. 59, # 3 p. 605 - 610
反应条件
boron trifluoride diethyl etherate in 1,4-dioxane
参考文献
Marta,M. et al.
Gazzetta Chimica Italiana, 1979 , vol. 109, p. 323 - 324
反应条件
1: chloroform; bromine / -5 - 0 °C
2: P2O5 / 98 °C / 30 Torr
View Scheme
参考文献
Petrow
Zhurnal Obshchei Khimii, 1943 , vol. 13, p. 741,748
Zhurnal Obshchei Khimii, 1945 , vol. 15, p. 931,937
Chem.Abstr., 1945 , p. 696,1946 6415
反应条件
(i) NaH, (ii) /BRN= 606498/; Multistep reaction;
参考文献
Salomon,R.G.; Reuter,J.M.
Journal of the American Chemical Society, 1977 , vol. 99, # 13 p. 4372 - 4379
反应条件
tetrakis(triphenylphosphine) palladium(0); tricyclo[3.3.1.13,7 ]-decane-1-carboxylic acid
Heating; Title compound not separated from byproducts.;
参考文献
Kazantzi, Georgia; Malamidou-Xenikaki, Elizabeth; Spyroudis, Spyros
Synlett, 2007 , # 3 p. 427 - 430
