2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
1: acidic aluminium oxide / 270 - 280 °C 2: ethyl magnesium bromide; diethyl ether View Scheme
参考文献
Alder; v. Brachel
Justus Liebigs Annalen der Chemie, 1957 , vol. 608, p. 195,198
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper (I) iodide in diethylamine 15 h; Ambient temperature;
参考文献
Lin, Bo-Nan; Huang, Shao-Hsien; Wu, Wei-Yi; Mou, Chung-Yuan; Tsai, Fu-Yu
Molecules, 2010 , vol. 15, # 12 p. 9157 - 9173
反应条件
CuI; triethylamine in ethylene glycol dimethyl ether
参考文献
Merck and Co., Inc.
Patent: US6774138 B2, 2004 ;
反应条件
copper(l) iodide; potassium carbonate; triphenylphosphine; palladium on activated charcoal 1) DME, H2O, 20 deg C, 30 min; 2) DME, H2O, 80 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Bleicher, Leo S.; Cosford, Nicholas D. P.; Herbaut, Audrey; Stuart McCallum; McDonald, Ian A.
Journal of Organic Chemistry, 1998 , vol. 63, # 4 p. 1109 - 1118
反应条件
propionic acid T=130°C; ortho-Claisen rearrangement; 12 h;
参考文献
Jonasson; Horvath; Backvall
Journal of the American Chemical Society, 2000 , vol. 122, # 40 p. 9600 - 9609
反应条件
T=20 - 145°C; 3.33 h; Inert atmosphere;
参考文献
Garcia, Pierre; Harrak, Youssef; Diab, Lisa; Cordier, Pierre; Ollivier, Cyril; Gandon, Vincent; Malacria, Max; Fensterbank, Louis; Aubert, Corinne
Organic Letters, 2011 , vol. 13, # 11 p. 2952 - 2955
反应条件
1: 30 percent / calcium chloride, Cu2Cl2 (95percent brown powder). copper bronze powder, conc. HCl / 1 h / 0 - 5 °C 2: 42 percent / sodamide / liquid ammonia; diethyl ether 3: 70 percent / copper bronze powder, Cu2Cl2, / dimethylformamide / 24 h / 4 °C 4: 80 percent / potassium hydroxide, H2 / W2 Raney nickel / ethanol / 18 h / 3102.9 Torr View Scheme
参考文献
Kopka, Ihor E.; Fataftah, Zacharia A.; Rathke, Michael W.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4616 - 4622
反应条件
1: n-butyl lithium 2: 70 percent / 0.3 mole percent CuCl2 * 2 H2O, 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 24 h / 0 °C View Scheme
参考文献
Godfrey, Jollie D.; Mueller, Richard H.; Sedergran, Thomas C.; Soundarajan, Nachimuthu; Colandrea, Vincent J.
Tetrahedron Letters, 1994 , vol. 35, # 35 p. 6405 - 6408
反应条件
Yield given. Multistep reaction;
参考文献
Karchava, A. V.; Maksimova, F. V.; Yurovskaya, M. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994 , vol. 30, # 10 p. 1195 - 1199
Khimiya Geterotsiklicheskikh Soedinenii, 1994 , # 10 p. 1378 - 1383
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine 16 h; Heating;
参考文献
Liu, Yao; Jiang, Shujun; Glusac, Ksenija; Powell, David H.; Anderson, Danielle F.; Schanze, Kirk S.
Journal of the American Chemical Society, 2002 , vol. 124, # 42 p. 12412 - 12413
