2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
1: 91 percent / aq. KOH; Br2 / hexane / 0.17 h / 4 °C 2: aq. n-BuNH2; CuCl; NH2OH*HCl / 0.17 h / 0 °C View Scheme
参考文献
Turlington, Mark; Du, Yuhao; Ostrum, Samuel G.; Santosh, Vishaka; Wren, Kathryne; Lin, Tony; Sabat, Michal; Pu, Lin
Journal of the American Chemical Society, 2011 , vol. 133, # 30 p. 11780 - 11794
反应条件
copper(l) iodide; tetrabutylammomium bromide; palladium diacetate; diisopropylamine T=70°C; 12 h;
参考文献
Weng, Yue; Cheng, Ben; He, Chuan; Lei, Aiwen
Angewandte Chemie - International Edition, 2012 , vol. 51, # 38 p. 9547 - 9551
反应条件
1: With copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride Sonogashira reaction; 20 h; Heating; 2: With sodium hydride in toluene 6 h; Heating;
参考文献
Komeyama, Kimihiro; Sasayama, Daisuke; Kawabata, Tomonori; Takehira, Katsuomi; Takaki, Ken
Chemical Communications, 2005 , # 5 p. 634 - 636
反应条件
diethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) chloride 12 h; Ambient temperature;
参考文献
Sarkar, Abhijit; Talwar, Satya S.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 24 p. 4141 - 4146
反应条件
dichloro bis(acetonitrile) palladium(II); 2-(di-tert-butylphosphino)-1-(2,6-diisopropylphenyl)-1H-imidazole; sodium carbonate in toluene T=90°C; Sonogashira coupling; Inert atmosphere;
参考文献
Torborg, Christian; Huang, Jun; Schulz, Thomas; Schaeffner, Benjamin; Zapf, Alexander; Spannenberg, Anke; Borner, Armin; Beller, Matthias
Chemistry - A European Journal, 2009 , vol. 15, # 6 p. 1329 - 1336
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine Inert atmosphereSealed flaskHeating;
参考文献
Zhou, Chao; Chen, Xiaopeng; Lu, Ping; Wang, Yanguang
Tetrahedron, 2012 , vol. 68, # 13 p. 2844 - 2850
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine 12 h;
参考文献
Sarkar; Manjunath; Kamath; Bhagwat; Babu; Rajalakshmi; Talwar
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 3 p. 360 - 362
反应条件
copper(l) iodide; triethylamine in dichloromethane T=25°C; 20 h;
参考文献
Ohe, Kouichi; Ishihara, Toshihisa; Chatani, Naoto; Kawasaki, Yoshikane; Murai, Shinji
Journal of Organic Chemistry, 1991 , vol. 56, # 6 p. 2267 - 2268
反应条件
1: Et3N / diethyl ether / 2 h / Ambient temperature 2: 94 percent / CuCl, Et3N / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Tamaru; Kimura; Tanaka; Kure; Yoshida
Bulletin of the Chemical Society of Japan, 1994 , vol. 67, # 10 p. 2838 - 2849
反应条件
1: 78 percent / propionic acid / 12 h / 130 °C 2: 95 percent / LiAlH4 / diethyl ether / 0.5 h 3: 78 percent / pyridine / 2 h / 0 °C View Scheme
参考文献
Jonasson; Horvath; Backvall
Journal of the American Chemical Society, 2000 , vol. 122, # 40 p. 9600 - 9609
