2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
1.1: 94 percent / CaCl2; CuCl2; copper bronze / aq. HCl / 1 h / 0 °C
2.1: EtONa / ethanol / 0.5 h / 60 °C
2.2: 62 percent / ethanol / 16.5 h / Heating
View Scheme
参考文献
Miller, Joseph A.; Coleman, Milton C.; Matthews, Randall S.
Journal of Organic Chemistry, 1993 , vol. 58, # 9 p. 2637 - 2639
反应条件
piperidine; caesium carbonate; [(P{(C6H11)3})2Pd(Cl)2] in dimethyl sulfoxide
T=120°C; Sonogashira coupling; 12 h;
参考文献
Yi, Chenyi; Hua, Ruimao; Zeng, Hanxiang; Huang, Qiufeng
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 10 p. 1738 - 1742
反应条件
piperidine; caesium carbonate; [(P{(C6H11)3})2Pd(Cl)2] in dimethyl sulfoxide
T=120°C; Sonogashira coupling; 12 h;
参考文献
Yi, Chenyi; Hua, Ruimao; Zeng, Hanxiang; Huang, Qiufeng
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 10 p. 1738 - 1742
反应条件
sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); N-benzyl-N,N,N-triethylammonium chloride in water; toluene
T=0 - 70°C; 168 h;
参考文献
Bookham, Jonathan L.; Smithies, Darren M.
Journal of Organometallic Chemistry, 1999 , vol. 577, # 2 p. 305 - 315
反应条件
1: 2-methyl-but-3-yn-2-ol With n-butyllithium in tetrahydrofuran; hexane
T=-30°C; 1 h;
2: cyclohexanone in tetrahydrofuran; hexane
T=-30 - 20°C;
参考文献
Koval'skaya; Kozlov; Dikusar
Russian Journal of General Chemistry, 2004 , vol. 74, # 6 p. 897 - 902
反应条件
1: 90 percent / PPh3, CuI / PdCl2 / triethylamine; dimethylformamide / 0.8 h / 85 °C
2: 91 percent / K2CO3 / ethanol / 1.5 h / Heating
3: 90 percent / 47percent HBr / CH2Cl2 / 0.5 h / Ambient temperature
View Scheme
参考文献
Sogawa, Akihiro; Tsukayama, Masao; Nozaki, Hiroshi; Nakayama, Mitsuru
Heterocycles, 1996 , vol. 43, # 1 p. 101 - 111
反应条件
1: 72 percent / hypophosphorous acid / benzene / 7 h / 80 °C
2: Br2 / H2O / 3 h
View Scheme
参考文献
Yudelevich, V. I.; Belakhov, V. V.; Komarov, E. V.; Ionin, B. I.; Petrov, A. A.
Doklady Chemistry, 1983 , vol. 269, p. 146 - 150
Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 269, # 6 p. 1377 - 1380
反应条件
in dichloromethane
T=-5 - 20°C; 16 h; Yield given. Yields of byproduct given;
参考文献
Bridges, Alexander J.
Tetrahedron Letters, 1980 , vol. 21, p. 4401 - 4404
反应条件
1: 56 percent / nBuLi
2: 56 percent / MeLi / diethyl ether / -70 °C
View Scheme
参考文献
Cutting, Ian; Parsons, Philip J.
Journal of the Chemical Society, Chemical Communications, 1983 , # 21 p. 1209 - 1210
反应条件
indium
1.) DMF, 2.) 80 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Araki, Shuki; Imai, Akira; Shimizu, Ken; Yamada, Masafumi; Mori, Akihiro; Butsugan, Yasuo
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1841 - 1847
