2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
参考文献
Spaeth; Schmid
Chemische Berichte, 1941 , vol. 74, p. 193,195
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine
Sonogashira Cross-Coupling; Inert atmosphereReflux;
参考文献
Smeyanov, Alexey; Schmidt, Andreas
Synthetic Communications, 2013 , vol. 43, # 20 p. 2809 - 2816
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride
T=100°C; 0.5 h;
参考文献
Inoue; Ohuchi; Yen; Imaizumi
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 11 p. 3518 - 3522
反应条件
1: 1-butyl-3-methylimidazolium hexafluorophosphate; N-methylpiperidine / dichlorobis(triphenylphosphine)palladium(II) / 1 h / 120 °C / 15200 Torr
2: 1-butyl-3-methylimidazolium hexafluorophosphate; N-methylpiperidine / dichlorobis(triphenylphosphine)palladium(II) / 1 h / 100 °C / 7600 Torr
View Scheme
参考文献
Saimoto, Hiroyuki; Hiyama, Tamejiro; Nozaki, Hitosi
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 10 p. 3078 - 3087
反应条件
carbon dioxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride
T=100°C; 8 h;
参考文献
Inoue, Yoshio; Taniguchi, Masaaki; Hashimoto, Harukichi; Ohuchi, Kunihiro; Imaizumi, Shin
Chemistry Letters, 1988 , p. 81 - 82
反应条件
carbon dioxide; triethylamine; [(PPh3)3Pd]
T=100°C; 8 h;
参考文献
Inoue, Yoshio; Taniguchi, Masaaki; Hashimoto, Harukichi; Ohuchi, Kunihiro; Imaizumi, Shin
Chemistry Letters, 1988 , p. 81 - 82
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide
1.) Et3N, 10 atm of CO2, 70 deg C, 3 h, 2.) 150 deg C, 1 h,; Yield given. Multistep reaction;
参考文献
Inoue, Yoshio; Ohuchi, Kunihiro; Imaizumi, Shin
Tetrahedron Letters, 1988 , vol. 29, # 46 p. 5941 - 5942
反应条件
boron trifluoride diethyl etherate; mercury(II) oxide
参考文献
Air Reduction Co.
Patent: US2703333 , 1954 ;
反应条件
1: 2-methyl-but-3-yn-2-ol With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride
T=50°C; Sonogashira coupling; 1 h;
2: 3-bromo-pyridine With potassium hydroxide; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride
T=110°C; Sonogashira coupling; 5 h;
参考文献
Novak, Zoltan; Nemes, Peter; Kotschy, Andras
Organic Letters, 2004 , vol. 6, # 26 p. 4917 - 4920
反应条件
(i) EtMgBr, (ii) /BRN= 1900390/; Multistep reaction;
参考文献
Kucherov,V.F. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1962 , p. 446 - 451
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1962 , p. 484 - 490
