2-甲基-3-丁炔-2-醇合成路线 （共 621 条）
反应条件
(i) nBuLi, CH2Cl2, (ii) N,N'-sulfanediyl-bis-phthalimide, (iii) aq. K2CO3, toluene; Multistep reaction;
参考文献
Buechi; Freidinger
Journal of the American Chemical Society, 1974 , vol. 96, # 10 p. 3332 - 3333
参考文献
Burrows et al.
Proceedings of the Chemical Society, London, 1959 , p. 150
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diisopropylamine
T=60°C; 6 h;
参考文献
Kim, Ho-Joong; Lee, Eunji; Kim, Min Gyu; Kim, Min-Cheol; Lee, Myongsoo; Sim, Eunji
Chemistry - A European Journal, 2008 , vol. 14, # 13 p. 3883 - 3888
反应条件
piperidine; palladium diacetate; tris(4-methylphenyl)-phosphine in 1-methyl-pyrrolidin-2-one; toluene
T=40°C; 16 h; Inert atmosphere; Reagent/catalystSolvent;
参考文献
Tartaggia, Stefano; Caporale, Andrea; Fontana, Francesco; Stabile, Paolo; Castellin, Andrea; De Lucchi, Ottorino
RSC Advances, 2013 , vol. 3, # 40 p. 18544 - 18549
反应条件
Yield given. Multistep reaction;
参考文献
Fleming, Ian; Higgins, Dick; Lawrence, Nicholas J.; Thomas, Andrew P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 24 p. 3331 - 3350
反应条件
und anschliessenden Behandeln mit Chlor-trimethyl-silan;
参考文献
Petrow et al.
Doklady Akademii Nauk SSSR, 1953 , vol. 93, p. 293,295
Chem.Abstr., 1954 , p. 13616
Full Text Show Details
Schostakowskii et al.
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1956 , p. 1271,1273
Chem.Abstr., 1957 , p. 5689
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, -65 deg C, 6 h
2: 14 percent / Hg/Nafion-H, H2O / ethanol / 25 °C
View Scheme
参考文献
Saimoto, Hiroyuki; Hiyama, Tamejiro; Nozaki, Hitosi
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 10 p. 3078 - 3087
反应条件
boron trifluoride diethyl etherate in toluene
T=100°C; 3 h;
参考文献
Haak, Edgar
European Journal of Organic Chemistry, 2008 , # 5 p. 788 - 792
反应条件
piperidine; caesium carbonate; [(P{(C6H11)3})2Pd(Cl)2] in dimethyl sulfoxide
T=120°C; Sonogashira coupling; 12 h;
参考文献
Yi, Chenyi; Hua, Ruimao; Zeng, Hanxiang; Huang, Qiufeng
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 10 p. 1738 - 1742
反应条件
1: 2-methyl-but-3-yn-2-ol With copper(l) iodide; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride
T=50°C; Sonogashira coupling; 1 h;
2: iodobenzene With potassium hydroxide; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride
T=110°C; Sonogashira coupling; 5 h;
参考文献
Novak, Zoltan; Nemes, Peter; Kotschy, Andras
Organic Letters, 2004 , vol. 6, # 26 p. 4917 - 4920
