3-羟基-3-甲基-2-丁酮合成路线 （共 82 条）
反应条件
lithium diisopropyl amide 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1 h; -78 deg C -> room temperature, 1 h; Yield given. Multistep reaction;
参考文献
Smith, Amos B.; Levenberg, Patricia A.; Jerris, Paula J.; Scarborough, Robert M.; Wovkulich, Peter M.
Journal of the American Chemical Society, 1981 , vol. 103, # 6 p. 1501 - 1513
反应条件
n-hexanethiol in n-heptane Ambient temperatureIrradiation; Quantum yield;
参考文献
Encinas, Maria V.; Rufs, Ana M.; Lissi, Eduardo A.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 457 - 460
反应条件
in acetonitrile-D3 Irradiation; Product distribution;
参考文献
Tsentalovich, Yu. P.; Yurkovskaya, A. V.; Frantsev, A. A.; Doctorov, A. B.; Sagdeev, R. Z.
Zeitschrift fuer Physikalische Chemie (Muenchen, Germany), 1993 , vol. 182, # 1/2 p. 119 - 130
反应条件
1: 2-methyl-2-hydroxy-butan-3-one; diethyl malonate With sodium ethanolate in ethanol T=20°C; 0.5 h; 2: 5-azapyrimidine in ethanol T=20°C; 3 h;
参考文献
Villemin, Didier; Cheikh, Nawel; Liao, Liang; Bar, Nathalie; Lohier, Jean-Francois; Sopkova, Jana; Choukchou-Braham, Noureddine; Mostefa-Kara, Bachir
Tetrahedron, 2012 , vol. 68, # 24 p. 4906 - 4918
反应条件
1: 485 °C / Pyrolysis.Reaktion des Essigsaeureesters 2: Raney nickel; ethanol / 20 - 32 °C / Hydrogenation.unter Druck View Scheme
参考文献
Hurd; McPhee
Journal of the American Chemical Society, 1949 , vol. 71, p. 400
反应条件
1: With sodium ethanolate in ethanol 0.0333333 h; microwave irradiation; 2: With hydrogenchloride in ethanol 0.5 h; microwave irradiation;
参考文献
Villemin, Didier; Liao, Liang
Synthetic Communications, 2003 , vol. 33, # 9 p. 1575 - 1585
反应条件
1: sodium ethanolate / ethanol / 20 h / 20 °C 2: hydrogenchloride / benzene 3: water / 3 h / Heating View Scheme
参考文献
Avetisyan; Alvandzhyan
Russian Journal of Organic Chemistry, 2011 , vol. 47, # 2 p. 308 - 311
反应条件
1: 76 percent / triethylamine / dimethylformamide / 18 h / Ambient temperature 2: n-butyllitium, diisopropylamine 3: 41 percent / chromium trioxide, pyridine / CH2Cl2 / 3 h / Ambient temperature 4: 41 percent / 10percent HCl, / H2O; tetrahydrofuran / Ambient temperature 5: diisopropylamine, n-butyllithium / THF, -78 deg C 6: dicyclohexylcarbodiimide, cuprous chloride / benzene / 26 h / Heating View Scheme
参考文献
Jerris, Paula J.; Smith, Amos B.
Journal of Organic Chemistry, 1981 , vol. 46, # 3 p. 577 - 585
反应条件
in acetonitrile-D3 Irradiation; Product distribution;
参考文献
Tsentalovich, Yu. P.; Yurkovskaya, A. V.; Frantsev, A. A.; Doctorov, A. B.; Sagdeev, R. Z.
Zeitschrift fuer Physikalische Chemie (Muenchen, Germany), 1993 , vol. 182, # 1/2 p. 119 - 130
反应条件
1: KCN 2: aq. HCl 3: H2O View Scheme
参考文献
Powell,J.E. et al.
Journal of Organic Chemistry, 1978 , vol. 43, p. 3166 - 3169
