3,5-二碘-THYRO乙酸合成路线 （共 23 条）
反应条件
1: Py / CCl4 2: MeSO2Cl 3: (i) (catalytic hydrogenation), (ii) NaNO2, H2SO4, (iii) aq. NaI, I2, CHCl3, urea 4: aq. HCl / acetic acid View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 8, p. 469 - 474
反应条件
1.1: pyridine; p-toluenesulfonyl chloride / 0.5 h / 95 - 100 °C 1.2: 2 h / 125 °C / Inert atmosphere 2.1: hydrogen / Lindlar catalyst / ethanol 3.1: sodium nitrite; sulfuric acid; acetic acid / 1.75 h / 0 °C 3.2: 1 h / 20 °C 4.1: phosphorus; hydrogen iodide; acetic acid / 1 h / Reflux View Scheme
反应条件
1: pyridine; copper diacetate; triethylamine / dichloromethane / |Molecular sieve 2: boron tribromide / dichloromethane / -78 - 20 °C View Scheme
反应条件
1: pyridine; copper diacetate; triethylamine / dichloromethane / |Molecular sieve 2: boron tribromide / dichloromethane / -78 - 20 °C View Scheme
反应条件
hydrogen iodide; acetic acid
参考文献
Journal of Organic Chemistry, , vol. 22, p. 1577,1580
反应条件
phosphorus; hydrogen iodide; acetic acid
参考文献
Biochemical Journal, , vol. 50, p. 438
反应条件
1: H2SO4; concentrated aqueous HNO3 2: pyridine / Erhitzen des erhaltenen Reaktionsgemisches mit 4-Methoxy-phenol 3: aqueous HCl; acetic acid 4: palladium/charcoal; acetic acid / Hydrogenation 5: NaNO2; H2SO4; acetic acid / Behandeln des Reaktionsgemisches mit NaI, Jod und Harnstoff in H2O unter Zusatz von CHCl3 6: aqueous HI; acetic acid View Scheme
参考文献
Journal of Organic Chemistry, , vol. 22, p. 1577,1580
反应条件
1: NaNO2; H2SO4; acetic acid / Behandeln des Reaktionsgemisches mit NaI, Jod und Harnstoff in H2O unter Zusatz von CHCl3 2: aqueous HI; acetic acid View Scheme
参考文献
Journal of Organic Chemistry, , vol. 22, p. 1577,1580
反应条件
1: palladium/charcoal; acetic acid / Hydrogenation 2: NaNO2; H2SO4; acetic acid / Behandeln des Reaktionsgemisches mit NaI, Jod und Harnstoff in H2O unter Zusatz von CHCl3 3: aqueous HI; acetic acid View Scheme
参考文献
Journal of Organic Chemistry, , vol. 22, p. 1577,1580
反应条件
1: KI; aqueous ethanol 2: aqueous HI; red phosphorus; acetic acid View Scheme
参考文献
Biochemical Journal, , vol. 50, p. 438
