N-苄氧羰基-L-谷氨酸合成路线 （共 80 条）
反应条件
1: 90 percent / toluenesulfonic acid / toluene / 3 h / Heating 2: thionyl chloride / CH2Cl2 / 0.5 h / Heating 3: pyridine / CH2Cl2 / 0.25 h / 20 °C 4: lithium hydroxide / tetrahydrofuran; H2O / 0.5 h / 5 °C 5: hydrogen / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 4 p. 1111 - 1118
反应条件
1: 94 percent / PTSA / benzene / Heating 2: 95 percent / NaOMe / methanol / Heating 3: 82 percent / Et3N / CH2Cl2 / -5 °C 4: 85 percent / diethyl ether / -5 °C 5: 97 percent / HCl / diethyl ether / -5 °C 6: 96 percent / NaBH4 / methanol 7: 66 percent / Et3N / CH2Cl2 8: 35 percent / NaH / dimethylformamide / 85 °C 9: K2CO3 / methanol View Scheme
参考文献
Bailey, Patrick D.; Bryans, Justin S.
Tetrahedron Letters, 1988 , vol. 29, # 18 p. 2231 - 2234
反应条件
1: 91 percent / TsOH / toluene / Heating 2: 95 percent / triethylamine, 4-dimethylamino-pyridine / CH2Cl2; 2-methyl-propan-2-ol / 4 h / Ambient temperature 3: NaOH / ethanol View Scheme
参考文献
Loffet, A.; Galeotti, N.; Jouin, P.; Castro, B.
Tetrahedron Letters, 1989 , vol. 30, # 49 p. 6859 - 6860
反应条件
1: DCC / tetrahydrofuran / 0 °C 2: dicyclohexylamine (DCHA) / tetrahydrofuran / 0 °C 3: 70percent perchloric acid / Ambient temperature 4: 100 percent / 1 M KOH / methanol 5: triethylamine / tetrahydrofuran / 1 h / 0 °C 6: sodium borohydride / tetrahydrofuran; H2O / 4 h / Ambient temperature View Scheme
参考文献
Dolence, E. Kurt; Minnick, Albert A.; Miller, Marvin J.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 461 - 464
参考文献
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
Patent: WO2004/50586 A1, 2004 ;
Location in patent: Page 6 ;
反应条件
methanesulfonic acid in dichloromethane 30 h; Ambient temperature;
参考文献
Hamada, Yasumasa; Shibata, Makoto; Sugiura, Tsuneyuki; Kato, Shinji; Shioiri, Takayuki
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1252 - 1255
反应条件
toluene-4-sulfonic acid in toluene 1.67 h; Heating;
参考文献
Luesch, Hendrik; Hoffmann, Dietmar; Hevel, Joan M.; Becker, Julia E.; Golakoti, Trimurtulu; Moore, Richard E.
Journal of Organic Chemistry, 2003 , vol. 68, # 1 p. 83 - 91
反应条件
toluene-4-sulfonic acid in toluene Heating;
参考文献
Loffet, A.; Galeotti, N.; Jouin, P.; Castro, B.
Tetrahedron Letters, 1989 , vol. 30, # 49 p. 6859 - 6860
参考文献
Kubasch, Niels; Schmidt, Richard R.
European Journal of Organic Chemistry, 2002 , # 16 p. 2710 - 2726
反应条件
1: 94 percent / PTSA / benzene / Heating 2: 95 percent / NaOMe / methanol / Heating 3: 82 percent / Et3N / CH2Cl2 / -5 °C 4: 85 percent / diethyl ether / -5 °C 5: 97 percent / HCl / diethyl ether / -5 °C 6: 96 percent / NaBH4 / methanol 7: 66 percent / Et3N / CH2Cl2 8: 35 percent / NaH / dimethylformamide / 85 °C 9: K2CO3 / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 18 p. 2231 - 2234
