6-氨基-2,3-二氟苯酚合成路线 （共 6 条）
反应条件
palladium monocarbide
参考文献
SmithKline Beecham Corporation
Patent: US6262113 B1, 2001 ;
US 6262113 B1
反应条件
hydrogen; palladium 10 on activated carbon in methanol; ethyl acetate 12 h;
参考文献
US2005/245530 A1, ;
Page/Page column 93 ;
US 20050245530 A1
参考文献
Adrio, Javier; Carretero, Juan C.; Garcia Ruano, Jose L.; Pallares, Antonio; Vicioso, Mercedes
Heterocycles, 1999 , vol. 51, # 7 p. 1563 - 1572
反应条件
1.1: 80 percent / ethanol / 1 h / Heating 2.1: 95 percent / NaH in oil,; LiClO4 / 18 h / 40 °C 3.1: 80 percent / triphenylphosphine,; DEAD / ethyl acetate / 5 h / 20 °C 4.1: Ac2O,; H2SO4 / 0.75 h / 50 °C 4.2: H2O / 15 h / Heating View Scheme
参考文献
Adrio, Javier; Carretero, Juan C.; Garcia Ruano, Jose L.; Pallares, Antonio; Vicioso, Mercedes
Heterocycles, 1999 , vol. 51, # 7 p. 1563 - 1572
反应条件
1.1: 80 percent / ethanol / 1 h / Heating 2.1: 95 percent / NaH in oil,; LiClO4 / 18 h / 40 °C 3.1: 80 percent / triphenylphosphine,; DEAD / ethyl acetate / 5 h / 20 °C 4.1: Ac2O,; H2SO4 / 0.75 h / 50 °C 4.2: H2O / 15 h / Heating 5.1: dimethylsulfoxide / 2 h / 100 °C View Scheme
参考文献
Adrio, Javier; Carretero, Juan C.; Garcia Ruano, Jose L.; Pallares, Antonio; Vicioso, Mercedes
Heterocycles, 1999 , vol. 51, # 7 p. 1563 - 1572
反应条件
1.1: 80 percent / ethanol / 1 h / Heating 2.1: NaH in oil,; LiClO4 / 18 h / 40 °C 3.1: triphenylphosphine,; DEAD / ethyl acetate / 5 h / 20 °C 4.1: Ac2O,; H2SO4 / 0.75 h / 50 °C 4.2: H2O / 15 h / Heating 5.1: dimethylsulfoxide / 2 h / 100 °C View Scheme
参考文献
Adrio, Javier; Carretero, Juan C.; Garcia Ruano, Jose L.; Pallares, Antonio; Vicioso, Mercedes
Heterocycles, 1999 , vol. 51, # 7 p. 1563 - 1572
