1: 88 percent / NH3 / tetrahydrofuran / -78 deg C to room t. 2: 45percent NaOH / benzene; H2O / Ambient temperature 3: benzene / 4 h / Heating View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1: 64.2 percent / p-TsOH / benzene / Heating; azeotropic dist.<br />2: 2) H₂O / 1) dioxane, 120 deg C, 5 h, 2) dioxane, reflux, 1 h<br />3: 55.2 percent / Ac₂O, azeotropic HBr in H₂O / 4 h / 140 &deg;C<br />4: 46.2 percent / NaOH / H₂O / 7 h / 110 &deg;C<br /> <br /> &nbsp;