N-苄氧羰基-L-苯丙氨酸合成路线 （共 122 条）
反应条件
boron trifluoride diethyl etherate in dichloromethane; cyclohexane
T=25°C; 96 h;
参考文献
Jensen, Knud J.; Alsina, Jordi; Songster, Michael F.; Vagner, Josef; Albericio, Fernando; Barany, George
Journal of the American Chemical Society, 1998 , vol. 120, # 22 p. 5441 - 5452
反应条件
sulfuric acid in dichloromethane
T=-60 - 20°C; 168 h;
参考文献
Negom Kouodom, Morelle; Ronconi, Luca; Celegato, Marta; Nardon, Chiara; Marchio, Luciano; Dou, Q. Ping; Aldinucci, Donatella; Formaggio, Fernando; Fregona, Dolores
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2212 - 2226
反应条件
4-(N,N-dimethlyamino)pyridine in tert-butyl alcohol
0.5 h;
参考文献
Takeda; Akiyama; Nakamura; Takizawa; Mizuno; Takayanagi; Harigaya
Synthesis, 1994 , # 10 p. 1063 - 1066
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane; tert-butyl alcohol
4 h; Ambient temperature;
参考文献
Loffet, A.; Galeotti, N.; Jouin, P.; Castro, B.
Tetrahedron Letters, 1989 , vol. 30, # 49 p. 6859 - 6860
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in N,N-dimethyl acetamide
T=55°C; 24 h; Yield given;
参考文献
Chevallet, Pierre; Garrouste, Patrick; Malawska, Barbara; Martinez, Jean
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7409 - 7412
反应条件
4-(N,N-dimethlyamino)pyridine in neat (no solvent)
Milling;
参考文献
Konnert, Laure; Lamaty, Frederic; Martinez, Jean; Colacino, Evelina
Journal of Organic Chemistry, 2014 , vol. 79, # 9 p. 4008 - 4017
反应条件
in dichloromethane
T=20°C; 14 h;
参考文献
Shen, Hao; Lu, Xing; Jiang, Ke-Zhi; Yang, Ke-Fang; Lu, Yixin; Zheng, Zhan-Jiang; Lai, Guo-Qiao; Xu, Li-Wen
Tetrahedron, 2012 , vol. 68, # 43 p. 8916 - 8923
反应条件
1: 1.) 1,1'-Carbonyldiimidazole / 1.) DMF, room temp., 2 h, 2.) overnight
2: H2, HCl / Pd/C / methanol / 4 h
View Scheme
参考文献
Lippke; Muller; Schunack
Archiv der Pharmazie, 1987 , vol. 320, # 2 p. 145 - 153
反应条件
1: 45 percent / DCC / acetonitrile / -10 °C
2: palladium / ethanol; cyclohexene / 0.5 h / Heating
3: 59 percent / DCC, 1-hydroxybenzotriazole / acetonitrile; dimethylformamide / -10 °C
4: palladium / ethanol / 0.5 h / Heating
5: 46 percent / dimethylformamide / 4 °C
View Scheme
参考文献
Okada; Ohta
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 2 p. 581 - 585
反应条件
1: N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 1 h; 2.) room temp, 1 h
2: 70 percent / TEA / dioxane / 20 h / Ambient temperature
3: 75 percent / H2 / Pd / acetic acid; methanol; H2O
View Scheme
参考文献
Ienaga; Higashiura; Kimura
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 3 p. 1249 - 1254
