1165952-91-9合成路线 （共 295 条）
反应条件
1: Cu2Cl2, nPrCO2Na, PdCl2, HC(OMe)3 / 2280 Torr 2: (hydrolysis) View Scheme
参考文献
Stille,J.K.; Divakaruni,R.
Journal of Organic Chemistry, 1979 , vol. 44, # 2 p. 3474 - 3482
反应条件
aluminum oxide; Ni(acac) T=200°C; 12 h; other dialkyl sulfoxides and 1,3-dienes; var. metal complexes and ligands; var. stoichiometry; Product distributionMechanism;
参考文献
Dzhemilev, U. M.; Kunakova, R. V.; Baibulatova, N. Z.; Tarasenko, A. E.; Mustafina, E. M.
Bull. Russ. Acad. Sci. Div. Chem. Sci. (Engl. Transl.), 1992 , vol. 41, # 1 p. 160 - 166,128 - 134
反应条件
1.1: tetrahydrofuran / 18 h / 60 °C 2.1: palladium on activated charcoal; hydrogen / ethyl acetate / 2 h 3.1: sodium hydroxide; water / methanol / 8 h / 60 °C 3.2: pH 1 4.1: acetic anhydride / 1.5 h / 100 °C 5.1: hydrazine hydrate; acetic acid; sodium acetate / 16 h / 100 °C 6.1: trichlorophosphate / 5 h / 110 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; TAN, Yumei; LUO, Huichao
Patent: WO2014/19344 A1, 2014 ;
反应条件
Ledwith–Weitz salt in dichloromethane; water T=0°C; Diels-Alder cycloaddition; 0.00277778 h;
参考文献
Gao; Bauld
Tetrahedron Letters, 2000 , vol. 41, # 32 p. 5997 - 6000
反应条件
in tetrahydrofuran T=200°C; hetero-Diels-Alder reaction; 22 h;
参考文献
Endeshaw, Molla Mellese; Hansen, Lars K.; Gautun, Odd R.
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 149 - 154
反应条件
Fe(CO)3*PhCH=CH(Ph)CHO in toluene T=70°C; Rate constant;
参考文献
Burkinshaw, Philip M.; Dixon, Denis T.; Howell, James A. S.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1980 , p. 999 - 1004
反应条件
perchloric acid in acetonitrile T=25°C; Equilibrium constantKinetics;
参考文献
Berlande
Bulletin de la Societe Chimique de France, 1942 , vol. <5> 9, p. 644,651, 652
反应条件
Cl2Ni(1,2-bis(diphenylphosphino)ethane); hydroxide; dihydrogen peroxide 1.) THF, r.t., 48 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Zaidlewicz, Marek; Meller, Jerzy
Tetrahedron Letters, 1997 , vol. 38, # 41 p. 7279 - 7282
反应条件
pyridine in toluene T=79 - 81°C; P=3677540 Torr; 16 h; Product distribution;
参考文献
Chemische Berichte, , vol. 113, # 11 p. 3666 - 3668
反应条件
1.1: tetrahydrofuran / 48 h / 20 °C 2.1: tetrahydrofuran / 11.5 h / -78 - 20 °C 2.2: 80.4 percent / ethanolamine / tetrahydrofuran / 8 h / 20 °C 3.1: aq. HCl / tetrahydrofuran / 10 h / 60 °C 4.1: NaBH4 / tetrahydrofuran; H2O / 0.5 h / 20 °C 5.1: 136 mg / triethylamine / CH2Cl2 / 10 h / 20 °C 6.1: 94 percent / 1,3-propanedithiol; aq. HCl / 2,2,2-trifluoro-ethanol / 4 h / 60 °C 7.1: 53 percent / triethylamine / CH2Cl2 / 12 h / 20 °C 8.1: Dess-Martin periodinane / CH2Cl2 / 2 h / 20 °C 9.1: 66 mg / NaH2PO4; NaClO2; 2-methyl-2-butene / 2-methyl-propan-2-ol; H2O; tetrahydrofuran / 1.5 h / 0 °C 10.1: K2CO3; MeOH / 15 h / 20 °C 11.1: 42.5 mg / pyridine; BOPCl / acetonitrile / 2 h / 20 °C 12.1: 57 percent / pyridine; Ph3PCl2 / acetonitrile / 18 h / 20 °C 13.1: 60 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / 20 °C 14.1: 56 percent / EXP-B1Y ketoreductase; NAD(1+); glucose dehydrogenase / glucose / dimethylsulfoxide; aq. phosphate buffer / 0.67 h / 37 - 39 °C / pH 6.9 View Scheme
参考文献
Ling, Taotao; Macherla, Venkat R.; Manam, Rama Rao; McArthur, Katherine A.; Potts, Barbara C. M.
Organic Letters, 2007 , vol. 9, # 12 p. 2289 - 2292
