3-(N-Boc-氨甲基)苯甲酸合成路线 （共 16 条）
反应条件
1: N,N-dimethyl-formamide / 12 h / 85 °C 2: hydrazine hydrate / methanol / 4 h / 25 °C / Reflux 3: sodium hydrogencarbonate / ethyl acetate; water / 1.17 h / pH 8 4: water; lithium hydroxide hydrate / tetrahydrofuran / 4 h / 25 - 50 °C View Scheme
参考文献
WO2011/21209 A1, ;
WO 2011/021209 A1
反应条件
1: hydrazine hydrate / methanol / 4 h / 25 °C / Reflux 2: sodium hydrogencarbonate / ethyl acetate; water / 1.17 h / pH 8 3: water; lithium hydroxide hydrate / tetrahydrofuran / 4 h / 25 - 50 °C View Scheme
参考文献
WO2011/21209 A1, ;
WO 2011/021209 A1
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran T=0°C; 0.166667 h; 2: With sodium tetrahydroborate in methanol 0.5 h;
参考文献
SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.
Patent: WO2008/5457 A2, 2008 ;
Location in patent: Page/Page column 56 ;
WO 2008/005457 A2
反应条件
in tetrahydrofuran T=20°C; 3 h;
参考文献
Mammen, Mathai; Hughes, Adam
Patent: US2004/242622 A1, 2004 ;
Location in patent: Page 35 ;
反应条件
silver(l) oxide in N,N-dimethyl-formamide T=45°C; 42 h;
参考文献
Jackson, Sharon; DeGrado, William; Dwivedi, Anil; Parthasarathy, Anju; Higley, Anne; Krywko, James; Rockwell, Arlene; Markwalder, Jay; Wells, Greg; Wexler, Ruth; Mousa, Shaker; Harlow, Richard
Journal of the American Chemical Society, 1994 , vol. 116, # 8 p. 3220 - 3230
反应条件
1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 25 °C 2: sodium acetate; pyridinium chlorochromate / dichloromethane / 6 h / 25 °C View Scheme
参考文献
ANTHEM BIOSCIENCES PRIVATE LIMITED
Patent: US2012/101099 A1, 2012 ;
