2-溴-1-(3-氯苯基)乙醇合成路线 （共 6 条）
反应条件
sodium hydroxide; Lipase QL; propionic acid anhydride 1.) t-butyl methyl ether, 35 deg C, 24 h, 2.) t-butyl methyl ether, RT, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tanaka, Ken; Yasuda, Mari
Tetrahedron Asymmetry, 1998 , vol. 9, # 18 p. 3275 - 3282
反应条件
potassium hydroxide in diethyl ether 0.5 h; Heating; Yield given;
参考文献
Perrone, Roberto; Berardi, Francesco; Leopoldo, Marcello; Tortorella, Vincenzo; Lograno, Marcello D.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3045 - 3049
反应条件
sodium tetrahydroborate in ethanol
T=0°C;
参考文献
Daoud; Osman; Karrar
Pharmazie, 1988 , vol. 43, # 7 p. 470 - 472
反应条件
potassium iodide in N,N-dimethyl-formamide
8 h; Heating;
参考文献
Tanaka, Ken; Yasuda, Mari
Tetrahedron Asymmetry, 1998 , vol. 9, # 18 p. 3275 - 3282
反应条件
1: Br2 / benzene / 1 h
2: 100 percent / NaBH4 / ethanol / 0 °C
View Scheme
参考文献
Daoud; Osman; Karrar
Pharmazie, 1988 , vol. 43, # 7 p. 470 - 472
反应条件
sodium hydroxide; Lipase QL; propionic acid anhydride
1.) t-butyl methyl ether, 35 deg C, 24 h, 2.) t-butyl methyl ether, RT, 2 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tanaka, Ken; Yasuda, Mari
Tetrahedron Asymmetry, 1998 , vol. 9, # 18 p. 3275 - 3282
