1,3,3-三甲基-2-亚甲基吲哚啉合成路线 （共 94 条）
反应条件
1: 1-nitroso-2-hydroxy-naphthalene With zinc(II) chloride in tetrahydrofuran; water
T=20°C; 0.333333 h;
2: piperidine in ethanol
Michael addition; 2 h; Reflux;
3: 1,3-dihydro-1,3,3-trimethyl-2-methyleneindoline With sodium sulfate in ethanol
20 h; RefluxInert atmosphere;
参考文献
Pang, Mei-Li; Zhang, Hui-Juan; Liu, Pei-Pei; Zou, Zhi-Hong; Han, Jie; Meng, Ji-Ben
Synthesis, 2010 , # 20 art. no. F08010SS, p. 3418 - 3422
反应条件
dimethyl sulfoxide; triethylamine in methanol
T=40°C; 20 h;
参考文献
Koshkin; Lokshin; Samat; Gromov; Fedorova
Synthesis, 2005 , # 11 art. no. Z21004SS, p. 1876 - 1880
反应条件
in 1,4-dioxane
Heating;
参考文献
Rickwood; Marsden; Ormsby; Staunton; Wood; Hepworth; Gabbutt
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 1994 , vol. 246, p. 17 - 24
反应条件
triethylamine in benzene
T=40°C; 2 h; 20 degC, overnight;
参考文献
Prizhiyalgovskaya, N. M.; Kon'kov, L. I.; Tarshits, D. L.; Salmina, S. V.; Segizova, N. T.; Suvorov, N. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 7 p. 751 - 754
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 7 p. 915 - 918
反应条件
xylene
T=84 - 100°C; Erhitzen des Reaktionsgemisches unter Druck auf 150grad;
参考文献
Coenen
Chemische Berichte, 1947 , vol. 80, p. 546,550
参考文献
Ferratini
Gazzetta Chimica Italiana, 1894 , vol. 24 II, p. 195
参考文献
Plancher
Chemische Berichte, 1898 , vol. 31, p. 1496
Gazzetta Chimica Italiana, 1898 , vol. 28 II, p. 372
Show Details
Ferratini
Gazzetta Chimica Italiana, 1894 , vol. 24 II, p. 195
参考文献
Piccinini
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1898 , vol. <5> 7 I, p. 359
Gazzetta Chimica Italiana, 1898 , vol. 28 II, p. 61
反应条件
triethylamine in benzene
T=60 - 80°C; 1 h;
参考文献
Tolmachev, A. A.; Babichenko, L. N.; Sheinkman, A. K.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1993 , vol. 29, # 4 p. 446 - 451
Khimiya Geterotsiklicheskikh Soedinenii, 1993 , # 4 p. 523 - 528
参考文献
Gal'bershtam, M. A.; Sidorov, A. P.; Przhiyalgovskaya, N. M.; Strokach, Yu. P.; Barachevskii, V. A.; et. al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 9 p. 923 - 928
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , # 9 p. 1205 - 1210
